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Features of wild-type human SOD1 limit interactions with misfolded aggregates of mouse G86R Sod1

Mutations in the gene encoding superoxide dismutase 1 (SOD1) account for about 20% of the cases of familial amyotrophic lateral sclerosis (fALS). It is well established that mutations in SOD1, associated with fALS, heighten the propensity of the protein to misfold and aggregate. Although aggregation...

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Detalles Bibliográficos
Autores principales:	Qualls, David A, Prudencio, Mercedes, Roberts, Brittany LT, Crosby, Keith, Brown, Hilda, Borchelt, David R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881023/ https://www.ncbi.nlm.nih.gov/pubmed/24341866 http://dx.doi.org/10.1186/1750-1326-8-46

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