Therapeutic expression of hairpins targeting apolipoprotein B100 induces phenotypic and transcriptome changes in murine liver

Constitutive expression of short hairpin RNAs (shRNAs) may cause cellular toxicity in vivo and using microRNA (miRNA) scaffolds can circumvent this problem. Previously, we have shown that embedding small interfering RNA sequences targeting apolipoprotein B100 (ApoB) in shRNA (shApoB) or miRNA (miApo...

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Detalles Bibliográficos
Autores principales: Maczuga, P, Verheij, J, van der Loos, C, van Logtenstein, R, Hooijer, G, Martier, R, Borel, F, Lubelski, J, Koornneef, A, Blits, B, van Deventer, S, Petry, H, Konstantinova, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881031/
https://www.ncbi.nlm.nih.gov/pubmed/24152580
http://dx.doi.org/10.1038/gt.2013.58

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881031/
https://www.ncbi.nlm.nih.gov/pubmed/24152580
http://dx.doi.org/10.1038/gt.2013.58

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