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C-reactive protein as a prognostic marker in chronic obstructive pulmonary disease

The present study aimed to evaluate whether circulating C-reactive protein (CRP) levels are a biomarker of systemic inflammation and a significant predictor of future chronic obstructive pulmonary disease (COPD) outcome. During the study, 116 patients with stable COPD and 35 age- and gender-matched...

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Autores principales: DENG, ZAI-CHUN, ZHAO, PENG, CAO, CHAO, SUN, SHI-FANG, ZHAO, FENG, LU, CHAO-YUE, MA, HONG-YING
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881036/
https://www.ncbi.nlm.nih.gov/pubmed/24396422
http://dx.doi.org/10.3892/etm.2013.1441
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author DENG, ZAI-CHUN
ZHAO, PENG
CAO, CHAO
SUN, SHI-FANG
ZHAO, FENG
LU, CHAO-YUE
MA, HONG-YING
author_facet DENG, ZAI-CHUN
ZHAO, PENG
CAO, CHAO
SUN, SHI-FANG
ZHAO, FENG
LU, CHAO-YUE
MA, HONG-YING
author_sort DENG, ZAI-CHUN
collection PubMed
description The present study aimed to evaluate whether circulating C-reactive protein (CRP) levels are a biomarker of systemic inflammation and a significant predictor of future chronic obstructive pulmonary disease (COPD) outcome. During the study, 116 patients with stable COPD and 35 age- and gender-matched healthy subjects with normal pulmonary function were observed. Patient follow-up was also performed to evaluate the strength of the associations between CRP levels and future outcomes. The observations from the present study showed that serum CRP levels were significantly higher in stable COPD patients than in control subjects (4.48±0.83 vs. 1.01±0.27 mg/l, respectively; P<0.05). In addition, it was identified that a serum CRP concentration of >3 mg/l is a poor prognostic variable of COPD compared with a CRP concentration of ≤3 mg/l [hazard ratio (HR), 2.71; 95% confidence interval (CI), 1.05–6.99; P<0.05]. A quantitative synthesis of four studies including 1,750 COPD patients was performed and statistically similar results were obtained (HR, 1.54; 95% CI, 1.14–2.07; P<0.01). The present study showed that circulating CRP levels are higher in stable COPD patients and, therefore, may be used as a long-term predictor of future outcomes. These observations highlight the importance of high sensitivity CRP assays in patients with stable COPD.
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spelling pubmed-38810362014-01-06 C-reactive protein as a prognostic marker in chronic obstructive pulmonary disease DENG, ZAI-CHUN ZHAO, PENG CAO, CHAO SUN, SHI-FANG ZHAO, FENG LU, CHAO-YUE MA, HONG-YING Exp Ther Med Articles The present study aimed to evaluate whether circulating C-reactive protein (CRP) levels are a biomarker of systemic inflammation and a significant predictor of future chronic obstructive pulmonary disease (COPD) outcome. During the study, 116 patients with stable COPD and 35 age- and gender-matched healthy subjects with normal pulmonary function were observed. Patient follow-up was also performed to evaluate the strength of the associations between CRP levels and future outcomes. The observations from the present study showed that serum CRP levels were significantly higher in stable COPD patients than in control subjects (4.48±0.83 vs. 1.01±0.27 mg/l, respectively; P<0.05). In addition, it was identified that a serum CRP concentration of >3 mg/l is a poor prognostic variable of COPD compared with a CRP concentration of ≤3 mg/l [hazard ratio (HR), 2.71; 95% confidence interval (CI), 1.05–6.99; P<0.05]. A quantitative synthesis of four studies including 1,750 COPD patients was performed and statistically similar results were obtained (HR, 1.54; 95% CI, 1.14–2.07; P<0.01). The present study showed that circulating CRP levels are higher in stable COPD patients and, therefore, may be used as a long-term predictor of future outcomes. These observations highlight the importance of high sensitivity CRP assays in patients with stable COPD. D.A. Spandidos 2014-02 2013-12-09 /pmc/articles/PMC3881036/ /pubmed/24396422 http://dx.doi.org/10.3892/etm.2013.1441 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
DENG, ZAI-CHUN
ZHAO, PENG
CAO, CHAO
SUN, SHI-FANG
ZHAO, FENG
LU, CHAO-YUE
MA, HONG-YING
C-reactive protein as a prognostic marker in chronic obstructive pulmonary disease
title C-reactive protein as a prognostic marker in chronic obstructive pulmonary disease
title_full C-reactive protein as a prognostic marker in chronic obstructive pulmonary disease
title_fullStr C-reactive protein as a prognostic marker in chronic obstructive pulmonary disease
title_full_unstemmed C-reactive protein as a prognostic marker in chronic obstructive pulmonary disease
title_short C-reactive protein as a prognostic marker in chronic obstructive pulmonary disease
title_sort c-reactive protein as a prognostic marker in chronic obstructive pulmonary disease
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881036/
https://www.ncbi.nlm.nih.gov/pubmed/24396422
http://dx.doi.org/10.3892/etm.2013.1441
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