MicroRNAs -the Next Generation Therapeutic Targets in Human Diseases

MicroRNAs (miRNAs), an abundant class of ~22-nucleotide non-coding RNAs, regulate the expression of genes at post transcriptional level. MiRNAs are important regulators of eukaryotic gene expression and therefore implicated in a wide range of biological processes. The miRNA-related genetic alteratio...

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Autores principales: Srinivasan, Sakthivel, Selvan, Subramanian Tamil, Archunan, Govindaraju, Gulyas, Balazs, Padmanabhan, Parasuraman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881095/
https://www.ncbi.nlm.nih.gov/pubmed/24396504
http://dx.doi.org/10.7150/thno.7026
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author Srinivasan, Sakthivel
Selvan, Subramanian Tamil
Archunan, Govindaraju
Gulyas, Balazs
Padmanabhan, Parasuraman
author_facet Srinivasan, Sakthivel
Selvan, Subramanian Tamil
Archunan, Govindaraju
Gulyas, Balazs
Padmanabhan, Parasuraman
author_sort Srinivasan, Sakthivel
collection PubMed
description MicroRNAs (miRNAs), an abundant class of ~22-nucleotide non-coding RNAs, regulate the expression of genes at post transcriptional level. MiRNAs are important regulators of eukaryotic gene expression and therefore implicated in a wide range of biological processes. The miRNA-related genetic alterations are possibly more implicated human diseases than currently appreciated. Genetic variants in miRNA target sites, called miRNA genes are identified to be associated with human diseases. This review discusses about the role of micro-RNA genes in various human diseases such as neurodegenerative disorders, cardio-vascular diseases, and metabolic disorders, and how they can be targeted as a new therapeutic tool in future with reference to drug discoveries/ development.
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spelling pubmed-38810952014-01-06 MicroRNAs -the Next Generation Therapeutic Targets in Human Diseases Srinivasan, Sakthivel Selvan, Subramanian Tamil Archunan, Govindaraju Gulyas, Balazs Padmanabhan, Parasuraman Theranostics Review MicroRNAs (miRNAs), an abundant class of ~22-nucleotide non-coding RNAs, regulate the expression of genes at post transcriptional level. MiRNAs are important regulators of eukaryotic gene expression and therefore implicated in a wide range of biological processes. The miRNA-related genetic alterations are possibly more implicated human diseases than currently appreciated. Genetic variants in miRNA target sites, called miRNA genes are identified to be associated with human diseases. This review discusses about the role of micro-RNA genes in various human diseases such as neurodegenerative disorders, cardio-vascular diseases, and metabolic disorders, and how they can be targeted as a new therapeutic tool in future with reference to drug discoveries/ development. Ivyspring International Publisher 2013-11-29 /pmc/articles/PMC3881095/ /pubmed/24396504 http://dx.doi.org/10.7150/thno.7026 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Review
Srinivasan, Sakthivel
Selvan, Subramanian Tamil
Archunan, Govindaraju
Gulyas, Balazs
Padmanabhan, Parasuraman
MicroRNAs -the Next Generation Therapeutic Targets in Human Diseases
title MicroRNAs -the Next Generation Therapeutic Targets in Human Diseases
title_full MicroRNAs -the Next Generation Therapeutic Targets in Human Diseases
title_fullStr MicroRNAs -the Next Generation Therapeutic Targets in Human Diseases
title_full_unstemmed MicroRNAs -the Next Generation Therapeutic Targets in Human Diseases
title_short MicroRNAs -the Next Generation Therapeutic Targets in Human Diseases
title_sort micrornas -the next generation therapeutic targets in human diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881095/
https://www.ncbi.nlm.nih.gov/pubmed/24396504
http://dx.doi.org/10.7150/thno.7026
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