Immune response to mutant neo-antigens: Cancer's lessons for aging

Extending observations on the immunogenicity of neo-antigens that arise in the course of oncogenesis and tumor progression, we suggest that somatic mutations affecting normal tissues also lead to generation of new epitopes. We hypothesize that, at least under inflammatory conditions, immune response...

Descripción completa

Detalles Bibliográficos
Autores principales: Geyer, Rory J, Tobet, Rebecca, Berlin, Richard D, Srivastava, Pramod K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Point of View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881104/
https://www.ncbi.nlm.nih.gov/pubmed/24404425
http://dx.doi.org/10.4161/onci.26382
_version_ 1782298163177062400
author Geyer, Rory J
Tobet, Rebecca
Berlin, Richard D
Srivastava, Pramod K
author_facet Geyer, Rory J
Tobet, Rebecca
Berlin, Richard D
Srivastava, Pramod K
author_sort Geyer, Rory J
collection PubMed
description Extending observations on the immunogenicity of neo-antigens that arise in the course of oncogenesis and tumor progression, we suggest that somatic mutations affecting normal tissues also lead to generation of new epitopes. We hypothesize that, at least under inflammatory conditions, immune responses against such neo-antigens may lead to the elimination or functional impairment of normal cells, thus contributing to aging.
format Online
Article
Text
id pubmed-3881104
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-38811042014-01-08 Immune response to mutant neo-antigens: Cancer's lessons for aging Geyer, Rory J Tobet, Rebecca Berlin, Richard D Srivastava, Pramod K Oncoimmunology Point of View Extending observations on the immunogenicity of neo-antigens that arise in the course of oncogenesis and tumor progression, we suggest that somatic mutations affecting normal tissues also lead to generation of new epitopes. We hypothesize that, at least under inflammatory conditions, immune responses against such neo-antigens may lead to the elimination or functional impairment of normal cells, thus contributing to aging. Landes Bioscience 2013-11-01 2013-10-15 /pmc/articles/PMC3881104/ /pubmed/24404425 http://dx.doi.org/10.4161/onci.26382 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Point of View
Geyer, Rory J
Tobet, Rebecca
Berlin, Richard D
Srivastava, Pramod K
Immune response to mutant neo-antigens: Cancer's lessons for aging
title Immune response to mutant neo-antigens: Cancer's lessons for aging
title_full Immune response to mutant neo-antigens: Cancer's lessons for aging
title_fullStr Immune response to mutant neo-antigens: Cancer's lessons for aging
title_full_unstemmed Immune response to mutant neo-antigens: Cancer's lessons for aging
title_short Immune response to mutant neo-antigens: Cancer's lessons for aging
title_sort immune response to mutant neo-antigens: cancer's lessons for aging
topic Point of View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881104/
https://www.ncbi.nlm.nih.gov/pubmed/24404425
http://dx.doi.org/10.4161/onci.26382
work_keys_str_mv AT geyerroryj immuneresponsetomutantneoantigenscancerslessonsforaging
AT tobetrebecca immuneresponsetomutantneoantigenscancerslessonsforaging
AT berlinrichardd immuneresponsetomutantneoantigenscancerslessonsforaging
AT srivastavapramodk immuneresponsetomutantneoantigenscancerslessonsforaging

Ejemplares similares