Preventing surgery-induced NK cell dysfunction and cancer metastases with influenza vaccination

Surgical resection is the mainstay of treatment for solid tumors, but the postoperative period is uniquely inclined to the formation of metastases, largely due to the suppression of natural killer (NK) cells. We found that preoperative influenza vaccination prevents postoperative NK-cell dysfunction...

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Autores principales: Tai, Lee-Hwa, Zhang, Jiqing, Auer, Rebecca C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881108/
https://www.ncbi.nlm.nih.gov/pubmed/24404430
http://dx.doi.org/10.4161/onci.26618
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author Tai, Lee-Hwa
Zhang, Jiqing
Auer, Rebecca C
author_facet Tai, Lee-Hwa
Zhang, Jiqing
Auer, Rebecca C
author_sort Tai, Lee-Hwa
collection PubMed
description Surgical resection is the mainstay of treatment for solid tumors, but the postoperative period is uniquely inclined to the formation of metastases, largely due to the suppression of natural killer (NK) cells. We found that preoperative influenza vaccination prevents postoperative NK-cell dysfunction, attenuating tumor dissemination in murine models and promoting the activation of NK cells in cancer patients.
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spelling pubmed-38811082014-01-08 Preventing surgery-induced NK cell dysfunction and cancer metastases with influenza vaccination Tai, Lee-Hwa Zhang, Jiqing Auer, Rebecca C Oncoimmunology Author's View Surgical resection is the mainstay of treatment for solid tumors, but the postoperative period is uniquely inclined to the formation of metastases, largely due to the suppression of natural killer (NK) cells. We found that preoperative influenza vaccination prevents postoperative NK-cell dysfunction, attenuating tumor dissemination in murine models and promoting the activation of NK cells in cancer patients. Landes Bioscience 2013-11-01 2013-10-10 /pmc/articles/PMC3881108/ /pubmed/24404430 http://dx.doi.org/10.4161/onci.26618 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Tai, Lee-Hwa
Zhang, Jiqing
Auer, Rebecca C
Preventing surgery-induced NK cell dysfunction and cancer metastases with influenza vaccination
title Preventing surgery-induced NK cell dysfunction and cancer metastases with influenza vaccination
title_full Preventing surgery-induced NK cell dysfunction and cancer metastases with influenza vaccination
title_fullStr Preventing surgery-induced NK cell dysfunction and cancer metastases with influenza vaccination
title_full_unstemmed Preventing surgery-induced NK cell dysfunction and cancer metastases with influenza vaccination
title_short Preventing surgery-induced NK cell dysfunction and cancer metastases with influenza vaccination
title_sort preventing surgery-induced nk cell dysfunction and cancer metastases with influenza vaccination
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881108/
https://www.ncbi.nlm.nih.gov/pubmed/24404430
http://dx.doi.org/10.4161/onci.26618
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