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Mucinous carcinoma occurring in the male breast
Male breast carcinoma is an uncommon neoplasm, accounting for 0.6% of all breast carcinomas. Invasive ductal carcinoma of no special type is the most common type of male breast carcinoma, and mucinous carcinoma occurring in the male breast is extremely rare. In the present study, we report a case of...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881201/ https://www.ncbi.nlm.nih.gov/pubmed/24396451 http://dx.doi.org/10.3892/ol.2013.1730 |
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author | ISHIDA, MITSUAKI UMEDA, TOMOKO KAWAI, YUKI MORI, TSUYOSHI KUBOTA, YOSHIHIRO ABE, HAJIME IWAI, MUNEO YOSHIDA, KEIKO KAGOTANI, AKIKO TANI, TOHRU OKABE, HIDETOSHI |
author_facet | ISHIDA, MITSUAKI UMEDA, TOMOKO KAWAI, YUKI MORI, TSUYOSHI KUBOTA, YOSHIHIRO ABE, HAJIME IWAI, MUNEO YOSHIDA, KEIKO KAGOTANI, AKIKO TANI, TOHRU OKABE, HIDETOSHI |
author_sort | ISHIDA, MITSUAKI |
collection | PubMed |
description | Male breast carcinoma is an uncommon neoplasm, accounting for 0.6% of all breast carcinomas. Invasive ductal carcinoma of no special type is the most common type of male breast carcinoma, and mucinous carcinoma occurring in the male breast is extremely rare. In the present study, we report a case of mucinous carcinoma of the male breast and discuss the clinicopathological features of this type of tumor. A 63-year-old Japanese male presented with a gradually enlarged nodule in the right breast. The resected breast specimen revealed pure mucinous carcinoma and immunohistochemical analyses demonstrated that tumor cells were positive for estrogen receptor (ER), but negative for progesterone receptor (PgR). In addition, HER2 expression was not amplified. Pure mucinous carcinoma is generally associated with a low incidence of lymph node or distant metastases, and excellent disease-free survival in females. However, certain cases of this type of tumor with axillary lymph node metastasis in the male breast have been reported. In addition, the immunoprofiles of mucinous carcinoma in males are fundamentally the same as those in females. More than 90% of cases show positive immunoreactivity for ER and/or PgR, and HER2 expression is not amplified. However, it has been reported that breast cancer in males is more frequently positive for ER than in females, and has less HER2 overexpression. The high rate of hormone receptor-positive breast cancer in males is considered to be due to similar conditions as those in breast cancer in postmenopausal women. The pathogenesis of male breast carcinoma, including mucinous carcinoma, remains unclear; therefore, additional clinicopathological studies are required. |
format | Online Article Text |
id | pubmed-3881201 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-38812012014-01-06 Mucinous carcinoma occurring in the male breast ISHIDA, MITSUAKI UMEDA, TOMOKO KAWAI, YUKI MORI, TSUYOSHI KUBOTA, YOSHIHIRO ABE, HAJIME IWAI, MUNEO YOSHIDA, KEIKO KAGOTANI, AKIKO TANI, TOHRU OKABE, HIDETOSHI Oncol Lett Articles Male breast carcinoma is an uncommon neoplasm, accounting for 0.6% of all breast carcinomas. Invasive ductal carcinoma of no special type is the most common type of male breast carcinoma, and mucinous carcinoma occurring in the male breast is extremely rare. In the present study, we report a case of mucinous carcinoma of the male breast and discuss the clinicopathological features of this type of tumor. A 63-year-old Japanese male presented with a gradually enlarged nodule in the right breast. The resected breast specimen revealed pure mucinous carcinoma and immunohistochemical analyses demonstrated that tumor cells were positive for estrogen receptor (ER), but negative for progesterone receptor (PgR). In addition, HER2 expression was not amplified. Pure mucinous carcinoma is generally associated with a low incidence of lymph node or distant metastases, and excellent disease-free survival in females. However, certain cases of this type of tumor with axillary lymph node metastasis in the male breast have been reported. In addition, the immunoprofiles of mucinous carcinoma in males are fundamentally the same as those in females. More than 90% of cases show positive immunoreactivity for ER and/or PgR, and HER2 expression is not amplified. However, it has been reported that breast cancer in males is more frequently positive for ER than in females, and has less HER2 overexpression. The high rate of hormone receptor-positive breast cancer in males is considered to be due to similar conditions as those in breast cancer in postmenopausal women. The pathogenesis of male breast carcinoma, including mucinous carcinoma, remains unclear; therefore, additional clinicopathological studies are required. D.A. Spandidos 2014-02 2013-12-05 /pmc/articles/PMC3881201/ /pubmed/24396451 http://dx.doi.org/10.3892/ol.2013.1730 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles ISHIDA, MITSUAKI UMEDA, TOMOKO KAWAI, YUKI MORI, TSUYOSHI KUBOTA, YOSHIHIRO ABE, HAJIME IWAI, MUNEO YOSHIDA, KEIKO KAGOTANI, AKIKO TANI, TOHRU OKABE, HIDETOSHI Mucinous carcinoma occurring in the male breast |
title | Mucinous carcinoma occurring in the male breast |
title_full | Mucinous carcinoma occurring in the male breast |
title_fullStr | Mucinous carcinoma occurring in the male breast |
title_full_unstemmed | Mucinous carcinoma occurring in the male breast |
title_short | Mucinous carcinoma occurring in the male breast |
title_sort | mucinous carcinoma occurring in the male breast |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881201/ https://www.ncbi.nlm.nih.gov/pubmed/24396451 http://dx.doi.org/10.3892/ol.2013.1730 |
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