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Effect of Atorvastatin-Eluting Stents in a Rabbit Iliac Artery Restenosis Model

Statins have pleiotropic effects, which include the inhibition of neointima hyperplasia, the inhibition of vascular inflammation, and platelet inhibition. The aim of this study was to examine the effect of an atorvastatin-eluting stent (AES) in a rabbit iliac artery overstretch restenosis model. Ten...

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Autores principales: Lim, Kyung Seob, Jeong, Myung Ho, Bae, In Ho, Park, Jun-Kyu, Park, Dae Sung, Kim, Jong Min, Kim, Jung Ha, Cho, Dong Lyun, Sim, Doo Sun, Park, Keun-Ho, Hong, Young Joon, Ahn, Youngkeun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chonnam National University Medical School 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881207/
https://www.ncbi.nlm.nih.gov/pubmed/24400214
http://dx.doi.org/10.4068/cmj.2013.49.3.118
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author Lim, Kyung Seob
Jeong, Myung Ho
Bae, In Ho
Park, Jun-Kyu
Park, Dae Sung
Kim, Jong Min
Kim, Jung Ha
Cho, Dong Lyun
Sim, Doo Sun
Park, Keun-Ho
Hong, Young Joon
Ahn, Youngkeun
author_facet Lim, Kyung Seob
Jeong, Myung Ho
Bae, In Ho
Park, Jun-Kyu
Park, Dae Sung
Kim, Jong Min
Kim, Jung Ha
Cho, Dong Lyun
Sim, Doo Sun
Park, Keun-Ho
Hong, Young Joon
Ahn, Youngkeun
author_sort Lim, Kyung Seob
collection PubMed
description Statins have pleiotropic effects, which include the inhibition of neointima hyperplasia, the inhibition of vascular inflammation, and platelet inhibition. The aim of this study was to examine the effect of an atorvastatin-eluting stent (AES) in a rabbit iliac artery overstretch restenosis model. Ten rabbits were used in this study (10 rabbits, 10 iliac arteries for each stent). An AES and paclitaxel-eluting stent (PES) were implanted in the left and right iliac arteries in a rabbit (2 stents in each rabbit). The stents were deployed with oversizing (stent/artery ratio 1.3:1), and histopathologic analysis was assessed at 28 days after stenting. There were no significant differences in the injury score, lumen area, or inflammation score. There were significant differences in the neointimal area (0.7±0.18 mm(2) in the AES group vs. 0.4±0.25 mm(2) in the PES group, p<0.01), in the percentage stenosis area (14.8±5.06% in the AES group vs. 10.5±6.80% in the PES group, p<0.05), and in the fibrin score (0.4±0.51 in the AES group vs. 2.7±0.48 in the PES group, p<0.001). Although the AES did not suppress neointimal hyperplasia compared with the PES, it showed a superior arterial healing effect in a rabbit iliac artery overstretch restenosis model.
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spelling pubmed-38812072014-01-07 Effect of Atorvastatin-Eluting Stents in a Rabbit Iliac Artery Restenosis Model Lim, Kyung Seob Jeong, Myung Ho Bae, In Ho Park, Jun-Kyu Park, Dae Sung Kim, Jong Min Kim, Jung Ha Cho, Dong Lyun Sim, Doo Sun Park, Keun-Ho Hong, Young Joon Ahn, Youngkeun Chonnam Med J Original Article Statins have pleiotropic effects, which include the inhibition of neointima hyperplasia, the inhibition of vascular inflammation, and platelet inhibition. The aim of this study was to examine the effect of an atorvastatin-eluting stent (AES) in a rabbit iliac artery overstretch restenosis model. Ten rabbits were used in this study (10 rabbits, 10 iliac arteries for each stent). An AES and paclitaxel-eluting stent (PES) were implanted in the left and right iliac arteries in a rabbit (2 stents in each rabbit). The stents were deployed with oversizing (stent/artery ratio 1.3:1), and histopathologic analysis was assessed at 28 days after stenting. There were no significant differences in the injury score, lumen area, or inflammation score. There were significant differences in the neointimal area (0.7±0.18 mm(2) in the AES group vs. 0.4±0.25 mm(2) in the PES group, p<0.01), in the percentage stenosis area (14.8±5.06% in the AES group vs. 10.5±6.80% in the PES group, p<0.05), and in the fibrin score (0.4±0.51 in the AES group vs. 2.7±0.48 in the PES group, p<0.001). Although the AES did not suppress neointimal hyperplasia compared with the PES, it showed a superior arterial healing effect in a rabbit iliac artery overstretch restenosis model. Chonnam National University Medical School 2013-12 2013-12-23 /pmc/articles/PMC3881207/ /pubmed/24400214 http://dx.doi.org/10.4068/cmj.2013.49.3.118 Text en © Chonnam Medical Journal, 2013 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lim, Kyung Seob
Jeong, Myung Ho
Bae, In Ho
Park, Jun-Kyu
Park, Dae Sung
Kim, Jong Min
Kim, Jung Ha
Cho, Dong Lyun
Sim, Doo Sun
Park, Keun-Ho
Hong, Young Joon
Ahn, Youngkeun
Effect of Atorvastatin-Eluting Stents in a Rabbit Iliac Artery Restenosis Model
title Effect of Atorvastatin-Eluting Stents in a Rabbit Iliac Artery Restenosis Model
title_full Effect of Atorvastatin-Eluting Stents in a Rabbit Iliac Artery Restenosis Model
title_fullStr Effect of Atorvastatin-Eluting Stents in a Rabbit Iliac Artery Restenosis Model
title_full_unstemmed Effect of Atorvastatin-Eluting Stents in a Rabbit Iliac Artery Restenosis Model
title_short Effect of Atorvastatin-Eluting Stents in a Rabbit Iliac Artery Restenosis Model
title_sort effect of atorvastatin-eluting stents in a rabbit iliac artery restenosis model
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881207/
https://www.ncbi.nlm.nih.gov/pubmed/24400214
http://dx.doi.org/10.4068/cmj.2013.49.3.118
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