Cargando…
Immunohistochemical Patterns in the Interfollicular Caucasian Scalps: Influences of Age, Gender, and Alopecia
Skin ageing and gender influences on the scalp have been seldom studied. We revisited the changes in the interfollicular scalp. The study was performed on a population of 650 volunteers (300 women and 350 men) for over 7 years. Three age groups were selected in both genders, namely, subjects aged 20...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881438/ https://www.ncbi.nlm.nih.gov/pubmed/24455724 http://dx.doi.org/10.1155/2013/769489 |
_version_ | 1782298211267903488 |
---|---|
author | Piérard-Franchimont, Claudine Loussouarn, Geneviève Panhard, Ségolène Saint Léger, Didier Mellul, Myriam Piérard, Gérald E. |
author_facet | Piérard-Franchimont, Claudine Loussouarn, Geneviève Panhard, Ségolène Saint Léger, Didier Mellul, Myriam Piérard, Gérald E. |
author_sort | Piérard-Franchimont, Claudine |
collection | PubMed |
description | Skin ageing and gender influences on the scalp have been seldom studied. We revisited the changes in the interfollicular scalp. The study was performed on a population of 650 volunteers (300 women and 350 men) for over 7 years. Three age groups were selected in both genders, namely, subjects aged 20–35, 50–60, and 60–70 years. The hair status was further considered according to nonalopecic and alopecic patterns and severity (discrete, moderate, and severe). Biopsies from the parietal area were processed for immunohistochemistry. Stromal cells were distinguished according to the presence of vimentin, Factor XIIIa, CD117, and versican. Blood and lymphatic vessels were highlighted by Ulex europaeus agglutinin-1 and human podoplanin immunoreactivities, respectively. Actinic elastosis was identified by the lysozyme coating of elastic fibres. The epidermis was explored using the CD44 variant 3 and Ki67 immunolabellings. Biplot analyses were performed. Immunohistochemistry revealed a prominent gender effect in young adults. Both Factor XIIIa+ dermal dendrocytes and the microvasculature size decreased with scalp ageing. Alopecia changes mimicked stress-induced premature senescence. |
format | Online Article Text |
id | pubmed-3881438 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38814382014-01-20 Immunohistochemical Patterns in the Interfollicular Caucasian Scalps: Influences of Age, Gender, and Alopecia Piérard-Franchimont, Claudine Loussouarn, Geneviève Panhard, Ségolène Saint Léger, Didier Mellul, Myriam Piérard, Gérald E. Biomed Res Int Research Article Skin ageing and gender influences on the scalp have been seldom studied. We revisited the changes in the interfollicular scalp. The study was performed on a population of 650 volunteers (300 women and 350 men) for over 7 years. Three age groups were selected in both genders, namely, subjects aged 20–35, 50–60, and 60–70 years. The hair status was further considered according to nonalopecic and alopecic patterns and severity (discrete, moderate, and severe). Biopsies from the parietal area were processed for immunohistochemistry. Stromal cells were distinguished according to the presence of vimentin, Factor XIIIa, CD117, and versican. Blood and lymphatic vessels were highlighted by Ulex europaeus agglutinin-1 and human podoplanin immunoreactivities, respectively. Actinic elastosis was identified by the lysozyme coating of elastic fibres. The epidermis was explored using the CD44 variant 3 and Ki67 immunolabellings. Biplot analyses were performed. Immunohistochemistry revealed a prominent gender effect in young adults. Both Factor XIIIa+ dermal dendrocytes and the microvasculature size decreased with scalp ageing. Alopecia changes mimicked stress-induced premature senescence. Hindawi Publishing Corporation 2013 2013-12-22 /pmc/articles/PMC3881438/ /pubmed/24455724 http://dx.doi.org/10.1155/2013/769489 Text en Copyright © 2013 Claudine Piérard-Franchimont et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Piérard-Franchimont, Claudine Loussouarn, Geneviève Panhard, Ségolène Saint Léger, Didier Mellul, Myriam Piérard, Gérald E. Immunohistochemical Patterns in the Interfollicular Caucasian Scalps: Influences of Age, Gender, and Alopecia |
title | Immunohistochemical Patterns in the Interfollicular Caucasian Scalps: Influences of Age, Gender, and Alopecia |
title_full | Immunohistochemical Patterns in the Interfollicular Caucasian Scalps: Influences of Age, Gender, and Alopecia |
title_fullStr | Immunohistochemical Patterns in the Interfollicular Caucasian Scalps: Influences of Age, Gender, and Alopecia |
title_full_unstemmed | Immunohistochemical Patterns in the Interfollicular Caucasian Scalps: Influences of Age, Gender, and Alopecia |
title_short | Immunohistochemical Patterns in the Interfollicular Caucasian Scalps: Influences of Age, Gender, and Alopecia |
title_sort | immunohistochemical patterns in the interfollicular caucasian scalps: influences of age, gender, and alopecia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881438/ https://www.ncbi.nlm.nih.gov/pubmed/24455724 http://dx.doi.org/10.1155/2013/769489 |
work_keys_str_mv | AT pierardfranchimontclaudine immunohistochemicalpatternsintheinterfollicularcaucasianscalpsinfluencesofagegenderandalopecia AT loussouarngenevieve immunohistochemicalpatternsintheinterfollicularcaucasianscalpsinfluencesofagegenderandalopecia AT panhardsegolene immunohistochemicalpatternsintheinterfollicularcaucasianscalpsinfluencesofagegenderandalopecia AT saintlegerdidier immunohistochemicalpatternsintheinterfollicularcaucasianscalpsinfluencesofagegenderandalopecia AT mellulmyriam immunohistochemicalpatternsintheinterfollicularcaucasianscalpsinfluencesofagegenderandalopecia AT pierardgeralde immunohistochemicalpatternsintheinterfollicularcaucasianscalpsinfluencesofagegenderandalopecia |