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Resistance Training for Diabetes Prevention and Therapy: Experimental Findings and Molecular Mechanisms

Type 2 diabetes mellitus (T2D) is characterized by insulin resistance, impaired glycogen synthesis, lipid accumulation, and impaired mitochondrial function. Exercise training has received increasing recognition as a cornerstone in the prevention and treatment of T2D. Emerging research suggests that...

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Detalles Bibliográficos
Autores principales: Strasser, Barbara, Pesta, Dominik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881442/
https://www.ncbi.nlm.nih.gov/pubmed/24455726
http://dx.doi.org/10.1155/2013/805217
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author Strasser, Barbara
Pesta, Dominik
author_facet Strasser, Barbara
Pesta, Dominik
author_sort Strasser, Barbara
collection PubMed
description Type 2 diabetes mellitus (T2D) is characterized by insulin resistance, impaired glycogen synthesis, lipid accumulation, and impaired mitochondrial function. Exercise training has received increasing recognition as a cornerstone in the prevention and treatment of T2D. Emerging research suggests that resistance training (RT) has the power to combat metabolic dysfunction in patients with T2D and seems to be an effective measure to improve overall metabolic health and reduce metabolic risk factors in diabetic patients. However, there is limited mechanistic insight into how these adaptations occur. This review provides an overview of the intervention data on the impact of RT on glucose metabolism. In addition, the molecular mechanisms that lead to adaptation in skeletal muscle in response to RT and that are associated with possible beneficial metabolic responses are discussed. Some of the beneficial adaptations exerted by RT include increased GLUT4 translocation in skeletal muscle, increased insulin sensitivity and hence restored metabolic flexibility. Increased energy expenditure and excess postexercise oxygen consumption in response to RT may be other beneficial effects. RT is increasingly establishing itself as an effective measure to improve overall metabolic health and reduce metabolic risk factors in diabetic patients.
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spelling pubmed-38814422014-01-20 Resistance Training for Diabetes Prevention and Therapy: Experimental Findings and Molecular Mechanisms Strasser, Barbara Pesta, Dominik Biomed Res Int Review Article Type 2 diabetes mellitus (T2D) is characterized by insulin resistance, impaired glycogen synthesis, lipid accumulation, and impaired mitochondrial function. Exercise training has received increasing recognition as a cornerstone in the prevention and treatment of T2D. Emerging research suggests that resistance training (RT) has the power to combat metabolic dysfunction in patients with T2D and seems to be an effective measure to improve overall metabolic health and reduce metabolic risk factors in diabetic patients. However, there is limited mechanistic insight into how these adaptations occur. This review provides an overview of the intervention data on the impact of RT on glucose metabolism. In addition, the molecular mechanisms that lead to adaptation in skeletal muscle in response to RT and that are associated with possible beneficial metabolic responses are discussed. Some of the beneficial adaptations exerted by RT include increased GLUT4 translocation in skeletal muscle, increased insulin sensitivity and hence restored metabolic flexibility. Increased energy expenditure and excess postexercise oxygen consumption in response to RT may be other beneficial effects. RT is increasingly establishing itself as an effective measure to improve overall metabolic health and reduce metabolic risk factors in diabetic patients. Hindawi Publishing Corporation 2013 2013-12-22 /pmc/articles/PMC3881442/ /pubmed/24455726 http://dx.doi.org/10.1155/2013/805217 Text en Copyright © 2013 B. Strasser and D. Pesta. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Strasser, Barbara
Pesta, Dominik
Resistance Training for Diabetes Prevention and Therapy: Experimental Findings and Molecular Mechanisms
title Resistance Training for Diabetes Prevention and Therapy: Experimental Findings and Molecular Mechanisms
title_full Resistance Training for Diabetes Prevention and Therapy: Experimental Findings and Molecular Mechanisms
title_fullStr Resistance Training for Diabetes Prevention and Therapy: Experimental Findings and Molecular Mechanisms
title_full_unstemmed Resistance Training for Diabetes Prevention and Therapy: Experimental Findings and Molecular Mechanisms
title_short Resistance Training for Diabetes Prevention and Therapy: Experimental Findings and Molecular Mechanisms
title_sort resistance training for diabetes prevention and therapy: experimental findings and molecular mechanisms
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881442/
https://www.ncbi.nlm.nih.gov/pubmed/24455726
http://dx.doi.org/10.1155/2013/805217
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