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Tamoxifen as an effective neuroprotectant against early brain injury and learning deficits induced by subarachnoid hemorrhage: possible involvement of inflammatory signaling

BACKGROUND: Tamoxifen, a selective estrogen receptor modulator, has successfully been used to treat several animal models of brain injury, but the underlying mechanisms remain unclear. This study was undertaken to evaluate the effect of tamoxifen on the toll-like receptor 4 (TLR4)- and nuclear facto...

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Detalles Bibliográficos
Autores principales: Sun, Xuebo, Ji, Chengyuan, Hu, Tong, Wang, Zhong, Chen, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881500/
https://www.ncbi.nlm.nih.gov/pubmed/24373431
http://dx.doi.org/10.1186/1742-2094-10-157