Oral Immunogenicity of Plant-Made Mycobacterium tuberculosis ESAT6 and CFP10

Two lines of transgenic carrot plants producing Mycobacterium tuberculosis proteins (ESAT6 and CFP10) have been constructed. The target proteins are present in carrot storage roots at a level not less than 0.056% of the total storage protein (TSP) for ESAT6 and 0.002% of TSP for CFP10. As has been s...

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Detalles Bibliográficos
Autores principales: Uvarova, Elena A., Belavin, Pavel A., Permyakova, Natalya V., Zagorskaya, Alla A., Nosareva, Olesya V., Kakimzhanova, Almagul A., Deineko, Elena V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881630/
https://www.ncbi.nlm.nih.gov/pubmed/24455687
http://dx.doi.org/10.1155/2013/316304
Descripción
Sumario:Two lines of transgenic carrot plants producing Mycobacterium tuberculosis proteins (ESAT6 and CFP10) have been constructed. The target proteins are present in carrot storage roots at a level not less than 0.056% of the total storage protein (TSP) for ESAT6 and 0.002% of TSP for CFP10. As has been shown, oral immunization of mice induces both the cell-mediated and humoral immunities. These data suggest that the proteins in question are appropriate as a candidate edible vaccine against tuberculosis.

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