Oral Immunogenicity of Plant-Made Mycobacterium tuberculosis ESAT6 and CFP10

Two lines of transgenic carrot plants producing Mycobacterium tuberculosis proteins (ESAT6 and CFP10) have been constructed. The target proteins are present in carrot storage roots at a level not less than 0.056% of the total storage protein (TSP) for ESAT6 and 0.002% of TSP for CFP10. As has been s...

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Autores principales: Uvarova, Elena A., Belavin, Pavel A., Permyakova, Natalya V., Zagorskaya, Alla A., Nosareva, Olesya V., Kakimzhanova, Almagul A., Deineko, Elena V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881630/
https://www.ncbi.nlm.nih.gov/pubmed/24455687
http://dx.doi.org/10.1155/2013/316304
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author Uvarova, Elena A.
Belavin, Pavel A.
Permyakova, Natalya V.
Zagorskaya, Alla A.
Nosareva, Olesya V.
Kakimzhanova, Almagul A.
Deineko, Elena V.
author_facet Uvarova, Elena A.
Belavin, Pavel A.
Permyakova, Natalya V.
Zagorskaya, Alla A.
Nosareva, Olesya V.
Kakimzhanova, Almagul A.
Deineko, Elena V.
author_sort Uvarova, Elena A.
collection PubMed
description Two lines of transgenic carrot plants producing Mycobacterium tuberculosis proteins (ESAT6 and CFP10) have been constructed. The target proteins are present in carrot storage roots at a level not less than 0.056% of the total storage protein (TSP) for ESAT6 and 0.002% of TSP for CFP10. As has been shown, oral immunization of mice induces both the cell-mediated and humoral immunities. These data suggest that the proteins in question are appropriate as a candidate edible vaccine against tuberculosis.
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spelling pubmed-38816302014-01-19 Oral Immunogenicity of Plant-Made Mycobacterium tuberculosis ESAT6 and CFP10 Uvarova, Elena A. Belavin, Pavel A. Permyakova, Natalya V. Zagorskaya, Alla A. Nosareva, Olesya V. Kakimzhanova, Almagul A. Deineko, Elena V. Biomed Res Int Research Article Two lines of transgenic carrot plants producing Mycobacterium tuberculosis proteins (ESAT6 and CFP10) have been constructed. The target proteins are present in carrot storage roots at a level not less than 0.056% of the total storage protein (TSP) for ESAT6 and 0.002% of TSP for CFP10. As has been shown, oral immunization of mice induces both the cell-mediated and humoral immunities. These data suggest that the proteins in question are appropriate as a candidate edible vaccine against tuberculosis. Hindawi Publishing Corporation 2013 2013-12-19 /pmc/articles/PMC3881630/ /pubmed/24455687 http://dx.doi.org/10.1155/2013/316304 Text en Copyright © 2013 Elena A. Uvarova et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Uvarova, Elena A.
Belavin, Pavel A.
Permyakova, Natalya V.
Zagorskaya, Alla A.
Nosareva, Olesya V.
Kakimzhanova, Almagul A.
Deineko, Elena V.
Oral Immunogenicity of Plant-Made Mycobacterium tuberculosis ESAT6 and CFP10
title Oral Immunogenicity of Plant-Made Mycobacterium tuberculosis ESAT6 and CFP10
title_full Oral Immunogenicity of Plant-Made Mycobacterium tuberculosis ESAT6 and CFP10
title_fullStr Oral Immunogenicity of Plant-Made Mycobacterium tuberculosis ESAT6 and CFP10
title_full_unstemmed Oral Immunogenicity of Plant-Made Mycobacterium tuberculosis ESAT6 and CFP10
title_short Oral Immunogenicity of Plant-Made Mycobacterium tuberculosis ESAT6 and CFP10
title_sort oral immunogenicity of plant-made mycobacterium tuberculosis esat6 and cfp10
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881630/
https://www.ncbi.nlm.nih.gov/pubmed/24455687
http://dx.doi.org/10.1155/2013/316304
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