Metastasis-associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells

Overexpression of the metastasis-associated gene 1 (MTA1) has previously been found to be associated with progression of various cancer types to the metastasis stage. The function of MTA1 in laryngeal squamous cell carcinoma (LSCC) remains unclear. To explore the significance of MTA1 in the invasion...

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Detalles Bibliográficos
Autores principales: ZHANG, HAILI, YANG, DONG, WANG, HAIJUAN, WEN, SHUXIN, LIU, JIAN, LUAN, QINGCHUN, HUANG, YIXUAN, WANG, BINQUAN, LIN, CHEN, QIAN, HAILI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881929/
https://www.ncbi.nlm.nih.gov/pubmed/24396455
http://dx.doi.org/10.3892/ol.2013.1729
Descripción
Sumario:Overexpression of the metastasis-associated gene 1 (MTA1) has previously been found to be associated with progression of various cancer types to the metastasis stage. The function of MTA1 in laryngeal squamous cell carcinoma (LSCC) remains unclear. To explore the significance of MTA1 in the invasion and migration processes in LSCC, gene transfection and RNA interference (RNAi) were performed to study the biological function of MTA1 in the LSCC cell line, HEP-2. Results showed that MTA1 promoted the invasion, adhesion and migration behavior of LSCC cells. RNAi against MTA1 significantly decreased the malignant phenotypes of cancer cells. MTA1 may be important in the process of LSCC invasion and metastasis.

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