Metastasis-associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells

Overexpression of the metastasis-associated gene 1 (MTA1) has previously been found to be associated with progression of various cancer types to the metastasis stage. The function of MTA1 in laryngeal squamous cell carcinoma (LSCC) remains unclear. To explore the significance of MTA1 in the invasion...

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Autores principales: ZHANG, HAILI, YANG, DONG, WANG, HAIJUAN, WEN, SHUXIN, LIU, JIAN, LUAN, QINGCHUN, HUANG, YIXUAN, WANG, BINQUAN, LIN, CHEN, QIAN, HAILI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881929/
https://www.ncbi.nlm.nih.gov/pubmed/24396455
http://dx.doi.org/10.3892/ol.2013.1729
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author ZHANG, HAILI
YANG, DONG
WANG, HAIJUAN
WEN, SHUXIN
LIU, JIAN
LUAN, QINGCHUN
HUANG, YIXUAN
WANG, BINQUAN
LIN, CHEN
QIAN, HAILI
author_facet ZHANG, HAILI
YANG, DONG
WANG, HAIJUAN
WEN, SHUXIN
LIU, JIAN
LUAN, QINGCHUN
HUANG, YIXUAN
WANG, BINQUAN
LIN, CHEN
QIAN, HAILI
author_sort ZHANG, HAILI
collection PubMed
description Overexpression of the metastasis-associated gene 1 (MTA1) has previously been found to be associated with progression of various cancer types to the metastasis stage. The function of MTA1 in laryngeal squamous cell carcinoma (LSCC) remains unclear. To explore the significance of MTA1 in the invasion and migration processes in LSCC, gene transfection and RNA interference (RNAi) were performed to study the biological function of MTA1 in the LSCC cell line, HEP-2. Results showed that MTA1 promoted the invasion, adhesion and migration behavior of LSCC cells. RNAi against MTA1 significantly decreased the malignant phenotypes of cancer cells. MTA1 may be important in the process of LSCC invasion and metastasis.
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spelling pubmed-38819292014-01-06 Metastasis-associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells ZHANG, HAILI YANG, DONG WANG, HAIJUAN WEN, SHUXIN LIU, JIAN LUAN, QINGCHUN HUANG, YIXUAN WANG, BINQUAN LIN, CHEN QIAN, HAILI Oncol Lett Articles Overexpression of the metastasis-associated gene 1 (MTA1) has previously been found to be associated with progression of various cancer types to the metastasis stage. The function of MTA1 in laryngeal squamous cell carcinoma (LSCC) remains unclear. To explore the significance of MTA1 in the invasion and migration processes in LSCC, gene transfection and RNA interference (RNAi) were performed to study the biological function of MTA1 in the LSCC cell line, HEP-2. Results showed that MTA1 promoted the invasion, adhesion and migration behavior of LSCC cells. RNAi against MTA1 significantly decreased the malignant phenotypes of cancer cells. MTA1 may be important in the process of LSCC invasion and metastasis. D.A. Spandidos 2014-02 2013-12-05 /pmc/articles/PMC3881929/ /pubmed/24396455 http://dx.doi.org/10.3892/ol.2013.1729 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
ZHANG, HAILI
YANG, DONG
WANG, HAIJUAN
WEN, SHUXIN
LIU, JIAN
LUAN, QINGCHUN
HUANG, YIXUAN
WANG, BINQUAN
LIN, CHEN
QIAN, HAILI
Metastasis-associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells
title Metastasis-associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells
title_full Metastasis-associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells
title_fullStr Metastasis-associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells
title_full_unstemmed Metastasis-associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells
title_short Metastasis-associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells
title_sort metastasis-associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881929/
https://www.ncbi.nlm.nih.gov/pubmed/24396455
http://dx.doi.org/10.3892/ol.2013.1729
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