Severe aplastic anemia preceding acute monocytic leukemia in an adult with acquired trisomy 21: A case report

The current case report presents a patient with acute monocytic leukemia (AML-M5) occurring 14 years following the successful treatment of severe aplastic anemia (SAA) with immunosuppressants and androgens. The patient was treated with induction chemotherapy, but did not achieve remission. The patie...

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Autores principales: GUO, DONGMEI, LIU, QINQIN, LI, BANBAN, TENG, QINGLIANG
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881932/
https://www.ncbi.nlm.nih.gov/pubmed/24396488
http://dx.doi.org/10.3892/ol.2013.1724
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author GUO, DONGMEI
LIU, QINQIN
LI, BANBAN
TENG, QINGLIANG
author_facet GUO, DONGMEI
LIU, QINQIN
LI, BANBAN
TENG, QINGLIANG
author_sort GUO, DONGMEI
collection PubMed
description The current case report presents a patient with acute monocytic leukemia (AML-M5) occurring 14 years following the successful treatment of severe aplastic anemia (SAA) with immunosuppressants and androgens. The patient was treated with induction chemotherapy, but did not achieve remission. The patient succumbed to central nervous system bleeding 2 weeks following the first cycle of chemotherapy. Chromosomal examination revealed 47,XX,+21[10]/46,XX[1]. To the best of our knowledge the present case is the first to be reported of SAA 14 years preceding AML-M5 with acquired trisomy 21.
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spelling pubmed-38819322014-01-06 Severe aplastic anemia preceding acute monocytic leukemia in an adult with acquired trisomy 21: A case report GUO, DONGMEI LIU, QINQIN LI, BANBAN TENG, QINGLIANG Oncol Lett Articles The current case report presents a patient with acute monocytic leukemia (AML-M5) occurring 14 years following the successful treatment of severe aplastic anemia (SAA) with immunosuppressants and androgens. The patient was treated with induction chemotherapy, but did not achieve remission. The patient succumbed to central nervous system bleeding 2 weeks following the first cycle of chemotherapy. Chromosomal examination revealed 47,XX,+21[10]/46,XX[1]. To the best of our knowledge the present case is the first to be reported of SAA 14 years preceding AML-M5 with acquired trisomy 21. D.A. Spandidos 2014-02 2013-12-03 /pmc/articles/PMC3881932/ /pubmed/24396488 http://dx.doi.org/10.3892/ol.2013.1724 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
GUO, DONGMEI
LIU, QINQIN
LI, BANBAN
TENG, QINGLIANG
Severe aplastic anemia preceding acute monocytic leukemia in an adult with acquired trisomy 21: A case report
title Severe aplastic anemia preceding acute monocytic leukemia in an adult with acquired trisomy 21: A case report
title_full Severe aplastic anemia preceding acute monocytic leukemia in an adult with acquired trisomy 21: A case report
title_fullStr Severe aplastic anemia preceding acute monocytic leukemia in an adult with acquired trisomy 21: A case report
title_full_unstemmed Severe aplastic anemia preceding acute monocytic leukemia in an adult with acquired trisomy 21: A case report
title_short Severe aplastic anemia preceding acute monocytic leukemia in an adult with acquired trisomy 21: A case report
title_sort severe aplastic anemia preceding acute monocytic leukemia in an adult with acquired trisomy 21: a case report
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881932/
https://www.ncbi.nlm.nih.gov/pubmed/24396488
http://dx.doi.org/10.3892/ol.2013.1724
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AT libanban severeaplasticanemiaprecedingacutemonocyticleukemiainanadultwithacquiredtrisomy21acasereport
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