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A Brief Overview of Preeclampsia
Preeclampsia (PE) is a leading cause of maternal mortality and morbidity worldwide. It occurs in women with first or multiple pregnancies and is characterized by new onset hypertension and proteinuria. Improper placentation is mainly responsible for the disease. If PE remains untreated, it moves tow...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elmer Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881982/ https://www.ncbi.nlm.nih.gov/pubmed/24400024 http://dx.doi.org/10.4021/jocmr1682w |
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author | Al-Jameil, Noura Aziz Khan, Farah Fareed Khan, Mohammad Tabassum, Hajera |
author_facet | Al-Jameil, Noura Aziz Khan, Farah Fareed Khan, Mohammad Tabassum, Hajera |
author_sort | Al-Jameil, Noura |
collection | PubMed |
description | Preeclampsia (PE) is a leading cause of maternal mortality and morbidity worldwide. It occurs in women with first or multiple pregnancies and is characterized by new onset hypertension and proteinuria. Improper placentation is mainly responsible for the disease. If PE remains untreated, it moves towards more serious condition known as eclampsia. Hypertension, diabetes mellitus, proteinuria, obesity, family history, nulliparity, multiple pregnancies and thrombotic vascular disease contribute as the risk factors for PE. PE triggered metabolic stress causes vascular injury, thus contributing to the development of cardiovascular disease (CVD) and/or chronic kidney disease (CKD) in future. This risk appears to be increased especially in women with a history of recurrent PE and eclampsia. Clinically increased serum levels of sFlt-1 and decreased placental growth factor (PIGF) and vascular endothelial growth factor (VEGF) represent the severe condition of PE. The clinical findings of sever PE are assorted by the presence of systemic endothelial dysfunction, microangiopathy, the liver (hemolysis, elevated liver function tests and low platelet count, namely HELLP syndrome) and the kidney (proteinuria). The early detection of PE is one of the most important goals in obstetrics. |
format | Online Article Text |
id | pubmed-3881982 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Elmer Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-38819822014-01-07 A Brief Overview of Preeclampsia Al-Jameil, Noura Aziz Khan, Farah Fareed Khan, Mohammad Tabassum, Hajera J Clin Med Res Review Preeclampsia (PE) is a leading cause of maternal mortality and morbidity worldwide. It occurs in women with first or multiple pregnancies and is characterized by new onset hypertension and proteinuria. Improper placentation is mainly responsible for the disease. If PE remains untreated, it moves towards more serious condition known as eclampsia. Hypertension, diabetes mellitus, proteinuria, obesity, family history, nulliparity, multiple pregnancies and thrombotic vascular disease contribute as the risk factors for PE. PE triggered metabolic stress causes vascular injury, thus contributing to the development of cardiovascular disease (CVD) and/or chronic kidney disease (CKD) in future. This risk appears to be increased especially in women with a history of recurrent PE and eclampsia. Clinically increased serum levels of sFlt-1 and decreased placental growth factor (PIGF) and vascular endothelial growth factor (VEGF) represent the severe condition of PE. The clinical findings of sever PE are assorted by the presence of systemic endothelial dysfunction, microangiopathy, the liver (hemolysis, elevated liver function tests and low platelet count, namely HELLP syndrome) and the kidney (proteinuria). The early detection of PE is one of the most important goals in obstetrics. Elmer Press 2014-02 2013-12-13 /pmc/articles/PMC3881982/ /pubmed/24400024 http://dx.doi.org/10.4021/jocmr1682w Text en Copyright 2013, Al-Jameil et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Al-Jameil, Noura Aziz Khan, Farah Fareed Khan, Mohammad Tabassum, Hajera A Brief Overview of Preeclampsia |
title | A Brief Overview of Preeclampsia |
title_full | A Brief Overview of Preeclampsia |
title_fullStr | A Brief Overview of Preeclampsia |
title_full_unstemmed | A Brief Overview of Preeclampsia |
title_short | A Brief Overview of Preeclampsia |
title_sort | brief overview of preeclampsia |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881982/ https://www.ncbi.nlm.nih.gov/pubmed/24400024 http://dx.doi.org/10.4021/jocmr1682w |
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