A new zebrafish model produced by TILLING of SOD1-related amyotrophic lateral sclerosis replicates key features of the disease and represents a tool for in vivo therapeutic screening

Mutations in the superoxide dismutase gene (SOD1) are one cause of familial amyotrophic lateral sclerosis [ALS; also known as motor neuron disease (MND)] in humans. ALS is a relentlessly progressive neurodegenerative disease and, to date, there are no neuroprotective therapies with significant impac...

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Detalles Bibliográficos
Autores principales: Da Costa, Marc M. J., Allen, Claire E., Higginbottom, Adrian, Ramesh, Tennore, Shaw, Pamela J., McDermott, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882050/
https://www.ncbi.nlm.nih.gov/pubmed/24092880
http://dx.doi.org/10.1242/dmm.012013

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