Cargando…
TopBP1/Dpb11 binds DNA anaphase bridges to prevent genome instability
DNA anaphase bridges are a potential source of genome instability that may lead to chromosome breakage or nondisjunction during mitosis. Two classes of anaphase bridges can be distinguished: DAPI-positive chromatin bridges and DAPI-negative ultrafine DNA bridges (UFBs). Here, we establish budding ye...
Autores principales: | Germann, Susanne M., Schramke, Vera, Pedersen, Rune Troelsgaard, Gallina, Irene, Eckert-Boulet, Nadine, Oestergaard, Vibe H., Lisby, Michael |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882784/ https://www.ncbi.nlm.nih.gov/pubmed/24379413 http://dx.doi.org/10.1083/jcb.201305157 |
Ejemplares similares
-
TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells
por: Pedersen, Rune Troelsgaard, et al.
Publicado: (2015) -
Emerging roles of the CIP2A–TopBP1 complex in genome integrity
por: Ummethum, Henning, et al.
Publicado: (2023) -
Dpb11, the budding yeast homolog of TopBP1, functions with the checkpoint clamp in recombination repair
por: Ogiwara, Hideaki, et al.
Publicado: (2006) -
TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity
por: Moudry, Pavel, et al.
Publicado: (2016) -
TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution
por: Broderick, Ronan, et al.
Publicado: (2015)