The Effects of Surfactant on Oxygenation in Term Infants with Respiratory Failure

OBJECTIVE: The objective of the study was to evaluate the effects of exogenous surfactant on respiratory indices in term infants with respiratory failure. METHODS: Consecutive 18 mechanically ventilated term infants, who received a single dose of exogenous surfactant were retrospectively included in...

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Autores principales: Beken, Serdar, Turkyılmaz, Canan, Koc, Esin, Hirfanoglu, Ibrahim M., Altuntas, Nilgun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2013
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883380/
https://www.ncbi.nlm.nih.gov/pubmed/24427504
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author Beken, Serdar
Turkyılmaz, Canan
Koc, Esin
Hirfanoglu, Ibrahim M.
Altuntas, Nilgun
author_facet Beken, Serdar
Turkyılmaz, Canan
Koc, Esin
Hirfanoglu, Ibrahim M.
Altuntas, Nilgun
author_sort Beken, Serdar
collection PubMed
description OBJECTIVE: The objective of the study was to evaluate the effects of exogenous surfactant on respiratory indices in term infants with respiratory failure. METHODS: Consecutive 18 mechanically ventilated term infants, who received a single dose of exogenous surfactant were retrospectively included into the study. The respiratory outcome of surfactant rescue therapy was evaluated by comparing respiratory indices before and six hours after surfactant administration. FINDINGS: Median oxygenation index (OI), mean alveolar pressure (MAP) and fraction of inspired oxygen (FiO(2)) values were significantly decreased (P<0.001); median arterial oxygen partial pressure (PaO(2)), arterial oxygen saturation (SaO(2)) and PaO(2)/FiO(2) values were significantly increased six hours after surfactant treatment (P<0.001). CONCLUSION: Rescue therapy with surfactant was found to be effective in the improvement of early respiratory indices in term infants with respiratory failure.
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spelling pubmed-38833802014-01-14 The Effects of Surfactant on Oxygenation in Term Infants with Respiratory Failure Beken, Serdar Turkyılmaz, Canan Koc, Esin Hirfanoglu, Ibrahim M. Altuntas, Nilgun Iran J Pediatr Short Communication OBJECTIVE: The objective of the study was to evaluate the effects of exogenous surfactant on respiratory indices in term infants with respiratory failure. METHODS: Consecutive 18 mechanically ventilated term infants, who received a single dose of exogenous surfactant were retrospectively included into the study. The respiratory outcome of surfactant rescue therapy was evaluated by comparing respiratory indices before and six hours after surfactant administration. FINDINGS: Median oxygenation index (OI), mean alveolar pressure (MAP) and fraction of inspired oxygen (FiO(2)) values were significantly decreased (P<0.001); median arterial oxygen partial pressure (PaO(2)), arterial oxygen saturation (SaO(2)) and PaO(2)/FiO(2) values were significantly increased six hours after surfactant treatment (P<0.001). CONCLUSION: Rescue therapy with surfactant was found to be effective in the improvement of early respiratory indices in term infants with respiratory failure. Tehran University of Medical Sciences 2013-08 /pmc/articles/PMC3883380/ /pubmed/24427504 Text en © 2013 Iranian Journal of Pediatrics & Tehran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Short Communication
Beken, Serdar
Turkyılmaz, Canan
Koc, Esin
Hirfanoglu, Ibrahim M.
Altuntas, Nilgun
The Effects of Surfactant on Oxygenation in Term Infants with Respiratory Failure
title The Effects of Surfactant on Oxygenation in Term Infants with Respiratory Failure
title_full The Effects of Surfactant on Oxygenation in Term Infants with Respiratory Failure
title_fullStr The Effects of Surfactant on Oxygenation in Term Infants with Respiratory Failure
title_full_unstemmed The Effects of Surfactant on Oxygenation in Term Infants with Respiratory Failure
title_short The Effects of Surfactant on Oxygenation in Term Infants with Respiratory Failure
title_sort effects of surfactant on oxygenation in term infants with respiratory failure
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883380/
https://www.ncbi.nlm.nih.gov/pubmed/24427504
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