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Improved antibacterial activity and biocompatibility on vancomycin-loaded TiO(2) nanotubes: in vivo and in vitro studies

The goal for current orthopedic implant research is to design implants that have not only good biocompatibility but also antibacterial properties. TiO(2) nanotubes (NTs) were fabricated on the titanium surface through electrochemical anodization, which added new properties, such as enhanced biocompa...

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Detalles Bibliográficos
Autores principales: Zhang, Hangzhou, Sun, Yu, Tian, Ang, Xue, Xiang Xin, Wang, Lin, Alquhali, Ali, Bai, Xizhuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883425/
https://www.ncbi.nlm.nih.gov/pubmed/24403827
http://dx.doi.org/10.2147/IJN.S53221
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author Zhang, Hangzhou
Sun, Yu
Tian, Ang
Xue, Xiang Xin
Wang, Lin
Alquhali, Ali
Bai, Xizhuang
author_facet Zhang, Hangzhou
Sun, Yu
Tian, Ang
Xue, Xiang Xin
Wang, Lin
Alquhali, Ali
Bai, Xizhuang
author_sort Zhang, Hangzhou
collection PubMed
description The goal for current orthopedic implant research is to design implants that have not only good biocompatibility but also antibacterial properties. TiO(2) nanotubes (NTs) were fabricated on the titanium surface through electrochemical anodization, which added new properties, such as enhanced biocompatibility and potential utility as drug nanoreservoirs. The aim of the present study was to investigate the antibacterial properties and biocompatibility of NTs loaded with vancomycin (NT-V), both in vitro and in vivo. Staphylococcus aureus was used to study the antibacterial properties of the NT-V. There were three study groups: the commercially pure titanium (Cp-Ti) group, the NT group (nonloaded vancomycin), and the NT-V group. We compared NT-V biocompatibility and antibacterial efficacy with those of the NT and Cp-Ti groups. Compared with Cp-Ti, NT-V showed good antibacterial effect both in vitro and in vivo. Although the NTs reduced the surface bacterial adhesion in vitro, implant infection still developed in in vivo studies. Furthermore, the results also revealed that both NTs and NT-V showed good biocompatibility. Therefore, the NTs loaded with antibiotic might be potentially used for future orthopedic implants.
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spelling pubmed-38834252014-01-08 Improved antibacterial activity and biocompatibility on vancomycin-loaded TiO(2) nanotubes: in vivo and in vitro studies Zhang, Hangzhou Sun, Yu Tian, Ang Xue, Xiang Xin Wang, Lin Alquhali, Ali Bai, Xizhuang Int J Nanomedicine Original Research The goal for current orthopedic implant research is to design implants that have not only good biocompatibility but also antibacterial properties. TiO(2) nanotubes (NTs) were fabricated on the titanium surface through electrochemical anodization, which added new properties, such as enhanced biocompatibility and potential utility as drug nanoreservoirs. The aim of the present study was to investigate the antibacterial properties and biocompatibility of NTs loaded with vancomycin (NT-V), both in vitro and in vivo. Staphylococcus aureus was used to study the antibacterial properties of the NT-V. There were three study groups: the commercially pure titanium (Cp-Ti) group, the NT group (nonloaded vancomycin), and the NT-V group. We compared NT-V biocompatibility and antibacterial efficacy with those of the NT and Cp-Ti groups. Compared with Cp-Ti, NT-V showed good antibacterial effect both in vitro and in vivo. Although the NTs reduced the surface bacterial adhesion in vitro, implant infection still developed in in vivo studies. Furthermore, the results also revealed that both NTs and NT-V showed good biocompatibility. Therefore, the NTs loaded with antibiotic might be potentially used for future orthopedic implants. Dove Medical Press 2013 2013-11-08 /pmc/articles/PMC3883425/ /pubmed/24403827 http://dx.doi.org/10.2147/IJN.S53221 Text en © 2013 Zhang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Zhang, Hangzhou
Sun, Yu
Tian, Ang
Xue, Xiang Xin
Wang, Lin
Alquhali, Ali
Bai, Xizhuang
Improved antibacterial activity and biocompatibility on vancomycin-loaded TiO(2) nanotubes: in vivo and in vitro studies
title Improved antibacterial activity and biocompatibility on vancomycin-loaded TiO(2) nanotubes: in vivo and in vitro studies
title_full Improved antibacterial activity and biocompatibility on vancomycin-loaded TiO(2) nanotubes: in vivo and in vitro studies
title_fullStr Improved antibacterial activity and biocompatibility on vancomycin-loaded TiO(2) nanotubes: in vivo and in vitro studies
title_full_unstemmed Improved antibacterial activity and biocompatibility on vancomycin-loaded TiO(2) nanotubes: in vivo and in vitro studies
title_short Improved antibacterial activity and biocompatibility on vancomycin-loaded TiO(2) nanotubes: in vivo and in vitro studies
title_sort improved antibacterial activity and biocompatibility on vancomycin-loaded tio(2) nanotubes: in vivo and in vitro studies
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883425/
https://www.ncbi.nlm.nih.gov/pubmed/24403827
http://dx.doi.org/10.2147/IJN.S53221
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