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Average CT in PET studies of colorectal cancer patients with metastasis in the liver and esophageal cancer patients

Average CT (ACT) and PET have a similar temporal resolution and it has been shown to improve registration of the CT and PET data for PET/CT imaging of the thorax. The purpose of this study was to quantify the effect of ACT attenuation correction on PET for gross tumor volume (GTV) delineation with s...

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Autores principales: Tonkopi, Elena, Chi, Pai‐Chun Melinda, Mawlawi, Osama, Riegel, Adam C., Rohren, Eric M., Macapinlac, Homer A., Pan, Tinsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883558/
https://www.ncbi.nlm.nih.gov/pubmed/20160693
http://dx.doi.org/10.1120/jacmp.v11i1.3073
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author Tonkopi, Elena
Chi, Pai‐Chun Melinda
Mawlawi, Osama
Riegel, Adam C.
Rohren, Eric M.
Macapinlac, Homer A.
Pan, Tinsu
author_facet Tonkopi, Elena
Chi, Pai‐Chun Melinda
Mawlawi, Osama
Riegel, Adam C.
Rohren, Eric M.
Macapinlac, Homer A.
Pan, Tinsu
author_sort Tonkopi, Elena
collection PubMed
description Average CT (ACT) and PET have a similar temporal resolution and it has been shown to improve registration of the CT and PET data for PET/CT imaging of the thorax. The purpose of this study was to quantify the effect of ACT attenuation correction on PET for gross tumor volume (GTV) delineation with standardized uptake value (SUV) for liver and esophageal lesions. Our study included 48 colorectal cancer patients with metastasis in the liver and 52 esophageal cancer patients. These patients underwent a routine PET/CT scan followed by a cine CT scan of the thoracic region for ACT. Differences between the two PET data sets ([Formula: see text] and [Formula: see text]) corrected with the helical CT (HCT) and ACT were quantified by analyzing image alignment, maximum SUV [Formula: see text] , and GTV. The 67% of the colorectal and 73% of the esophageal studies demonstrated misregistration between the [Formula: see text] and HCT data. ACT was effective in removing misregistration artifacts in 65% of the misregisted colorectal and in 76% of the misregisted esophageal cancer patients. Misregistration between the CT and PET data affected GTVs due to the change in [Formula: see text] with ACT. A change of [Formula: see text] greater than 20% between [Formula: see text] and [Formula: see text] was found in 15% of the colorectal and 17% of the esophageal cases. Our results demonstrated a more pronounced effect of misregistration for the smaller lesions [Formula: see text] near the diaphragm [Formula: see text]. ACT was effective in improving registration between the CT and PET data in PET/CT for the colorectal and esophageal cancer patients. PACS number: 87.58.Fg
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spelling pubmed-38835582018-04-02 Average CT in PET studies of colorectal cancer patients with metastasis in the liver and esophageal cancer patients Tonkopi, Elena Chi, Pai‐Chun Melinda Mawlawi, Osama Riegel, Adam C. Rohren, Eric M. Macapinlac, Homer A. Pan, Tinsu J Appl Clin Med Phys Medical Imaging Average CT (ACT) and PET have a similar temporal resolution and it has been shown to improve registration of the CT and PET data for PET/CT imaging of the thorax. The purpose of this study was to quantify the effect of ACT attenuation correction on PET for gross tumor volume (GTV) delineation with standardized uptake value (SUV) for liver and esophageal lesions. Our study included 48 colorectal cancer patients with metastasis in the liver and 52 esophageal cancer patients. These patients underwent a routine PET/CT scan followed by a cine CT scan of the thoracic region for ACT. Differences between the two PET data sets ([Formula: see text] and [Formula: see text]) corrected with the helical CT (HCT) and ACT were quantified by analyzing image alignment, maximum SUV [Formula: see text] , and GTV. The 67% of the colorectal and 73% of the esophageal studies demonstrated misregistration between the [Formula: see text] and HCT data. ACT was effective in removing misregistration artifacts in 65% of the misregisted colorectal and in 76% of the misregisted esophageal cancer patients. Misregistration between the CT and PET data affected GTVs due to the change in [Formula: see text] with ACT. A change of [Formula: see text] greater than 20% between [Formula: see text] and [Formula: see text] was found in 15% of the colorectal and 17% of the esophageal cases. Our results demonstrated a more pronounced effect of misregistration for the smaller lesions [Formula: see text] near the diaphragm [Formula: see text]. ACT was effective in improving registration between the CT and PET data in PET/CT for the colorectal and esophageal cancer patients. PACS number: 87.58.Fg John Wiley and Sons Inc. 2010-02-04 /pmc/articles/PMC3883558/ /pubmed/20160693 http://dx.doi.org/10.1120/jacmp.v11i1.3073 Text en © 2010 The Authors. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Medical Imaging
Tonkopi, Elena
Chi, Pai‐Chun Melinda
Mawlawi, Osama
Riegel, Adam C.
Rohren, Eric M.
Macapinlac, Homer A.
Pan, Tinsu
Average CT in PET studies of colorectal cancer patients with metastasis in the liver and esophageal cancer patients
title Average CT in PET studies of colorectal cancer patients with metastasis in the liver and esophageal cancer patients
title_full Average CT in PET studies of colorectal cancer patients with metastasis in the liver and esophageal cancer patients
title_fullStr Average CT in PET studies of colorectal cancer patients with metastasis in the liver and esophageal cancer patients
title_full_unstemmed Average CT in PET studies of colorectal cancer patients with metastasis in the liver and esophageal cancer patients
title_short Average CT in PET studies of colorectal cancer patients with metastasis in the liver and esophageal cancer patients
title_sort average ct in pet studies of colorectal cancer patients with metastasis in the liver and esophageal cancer patients
topic Medical Imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883558/
https://www.ncbi.nlm.nih.gov/pubmed/20160693
http://dx.doi.org/10.1120/jacmp.v11i1.3073
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