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Decreased Mutation Frequencies among Immunoglobulin G Variable Region Genes during Viremic HIV-1 Infection

BACKGROUND/OBJECTIVE: HIV-1 infection is complicated by high rates of opportunistic infections against which specific antibodies contribute to immune defense. Antibody function depends on somatic hypermutation (SHM) of variable regions of immunoglobulin heavy chain genes (V(H)-D-J). We characterized...

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Detalles Bibliográficos
Autores principales:	Bowers, Elisabeth, Scamurra, Ronald W., Asrani, Anil, Beniguel, Lydie, MaWhinney, Samantha, Keays, Kathryne M., Thurn, Joseph R., Janoff, Edward N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883639/ https://www.ncbi.nlm.nih.gov/pubmed/24409278 http://dx.doi.org/10.1371/journal.pone.0081913

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