Nuclear Factor κB is Required for Tumor Growth Inhibition Mediated by Enavatuzumab (PDL192), a Humanized Monoclonal Antibody to TweakR

TweakR is a TNF receptor family member, whose natural ligand is the multifunctional cytokine TWEAK. The growth inhibitory activity observed following TweakR stimulation in certain cancer cell lines and the overexpression of TweakR in many solid tumor types led to the development of enavatuzumab (PDL...

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Detalles Bibliográficos
Autores principales: Purcell, James W., Kim, Han K., Tanlimco, Sonia G., Doan, Minhtam, Fox, Melvin, Lambert, Peter, Chao, Debra T., Sho, Mien, Wilson, Keith E., Starling, Gary C., Culp, Patricia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884146/
https://www.ncbi.nlm.nih.gov/pubmed/24409185
http://dx.doi.org/10.3389/fimmu.2013.00505

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