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Eccrine Porocarcinoma: Clinical and Pathological Report of Eight Cases

BACKGROUND: Eccrine porocarcinoma (EPC), a slow-growing carcinoma of the sweat gland, is a rare condition documented only in a small number of case series. Due to its rarity, guidelines and specific recommendations are not widely available. Accordingly, many dermatologists encounter difficulty in di...

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Autores principales: Kurashige, Yuta, Minemura, Tokuya, Nagatani, Tetsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884174/
https://www.ncbi.nlm.nih.gov/pubmed/24403888
http://dx.doi.org/10.1159/000355606
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author Kurashige, Yuta
Minemura, Tokuya
Nagatani, Tetsuo
author_facet Kurashige, Yuta
Minemura, Tokuya
Nagatani, Tetsuo
author_sort Kurashige, Yuta
collection PubMed
description BACKGROUND: Eccrine porocarcinoma (EPC), a slow-growing carcinoma of the sweat gland, is a rare condition documented only in a small number of case series. Due to its rarity, guidelines and specific recommendations are not widely available. Accordingly, many dermatologists encounter difficulty in diagnosing and treating EPC. The aim of this study is to report the clinical and pathological features of EPC in order to contribute to the body of information currently available on the subject. PATIENTS AND METHODS: From 2003 to 2013, 8 Japanese patients were diagnosed with EPC at the Department of Dermatology in the Hachioji Medical Center of Tokyo Medical University. Patient data, including clinical manifestations, histopathological findings, immunohistochemical results, treatment method, and clinical course were collected and documented. RESULTS: The mean age of the patients (6 males and 2 females) was 72.6 years. The duration of the lesions ranged from 4 months to 5 years (mean: 3.5 years). All of the lesions clinically presented with erosive reddish nodules (mean size: 39.0 mm). Initial CT imaging revealed that 1 case had multiple distant metastases. Surgical resection was performed for all primary lesions and follow-up observations were available in all cases (mean: 10.9 months). One case with distal metastases underwent both radiation therapy and chemotherapy, but nevertheless succumbed to the disease. CONCLUSION: The EPC cases in our department presented a versatile clinical appearance and characteristic histopathological features.
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spelling pubmed-38841742014-01-08 Eccrine Porocarcinoma: Clinical and Pathological Report of Eight Cases Kurashige, Yuta Minemura, Tokuya Nagatani, Tetsuo Case Rep Dermatol Published online: October, 2013 BACKGROUND: Eccrine porocarcinoma (EPC), a slow-growing carcinoma of the sweat gland, is a rare condition documented only in a small number of case series. Due to its rarity, guidelines and specific recommendations are not widely available. Accordingly, many dermatologists encounter difficulty in diagnosing and treating EPC. The aim of this study is to report the clinical and pathological features of EPC in order to contribute to the body of information currently available on the subject. PATIENTS AND METHODS: From 2003 to 2013, 8 Japanese patients were diagnosed with EPC at the Department of Dermatology in the Hachioji Medical Center of Tokyo Medical University. Patient data, including clinical manifestations, histopathological findings, immunohistochemical results, treatment method, and clinical course were collected and documented. RESULTS: The mean age of the patients (6 males and 2 females) was 72.6 years. The duration of the lesions ranged from 4 months to 5 years (mean: 3.5 years). All of the lesions clinically presented with erosive reddish nodules (mean size: 39.0 mm). Initial CT imaging revealed that 1 case had multiple distant metastases. Surgical resection was performed for all primary lesions and follow-up observations were available in all cases (mean: 10.9 months). One case with distal metastases underwent both radiation therapy and chemotherapy, but nevertheless succumbed to the disease. CONCLUSION: The EPC cases in our department presented a versatile clinical appearance and characteristic histopathological features. S. Karger AG 2013-10-04 /pmc/articles/PMC3884174/ /pubmed/24403888 http://dx.doi.org/10.1159/000355606 Text en Copyright © 2013 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: October, 2013
Kurashige, Yuta
Minemura, Tokuya
Nagatani, Tetsuo
Eccrine Porocarcinoma: Clinical and Pathological Report of Eight Cases
title Eccrine Porocarcinoma: Clinical and Pathological Report of Eight Cases
title_full Eccrine Porocarcinoma: Clinical and Pathological Report of Eight Cases
title_fullStr Eccrine Porocarcinoma: Clinical and Pathological Report of Eight Cases
title_full_unstemmed Eccrine Porocarcinoma: Clinical and Pathological Report of Eight Cases
title_short Eccrine Porocarcinoma: Clinical and Pathological Report of Eight Cases
title_sort eccrine porocarcinoma: clinical and pathological report of eight cases
topic Published online: October, 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884174/
https://www.ncbi.nlm.nih.gov/pubmed/24403888
http://dx.doi.org/10.1159/000355606
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