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(2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-methyltetrahydrofuran-3,4-diol
The molecular structure of the title compound, C(11)H(13)IN(4)O(3), shows a ribofuranosyl–pyrrolo O—C—N—C torsion angle of 59.1 (3)°, with the central C—N bond length being 1.446 (3) Å. The C—I bond length is 2.072 (2) Å. The amino group is coplanar with the attached aromatic ring [C—N—C—N torsio...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884313/ https://www.ncbi.nlm.nih.gov/pubmed/24454089 http://dx.doi.org/10.1107/S1600536813027931 |
Sumario: | The molecular structure of the title compound, C(11)H(13)IN(4)O(3), shows a ribofuranosyl–pyrrolo O—C—N—C torsion angle of 59.1 (3)°, with the central C—N bond length being 1.446 (3) Å. The C—I bond length is 2.072 (2) Å. The amino group is coplanar with the attached aromatic ring [C—N—C—N torsion angle = −178.8 (2)°] and forms an intramolecular N—H⋯I hydrogen bond. In the crystal, O—H⋯N and N—H⋯O hydrogen bonds link the molecules into puckered layers parallel to (001). These layers are bound to each other by secondary I⋯O interactions [3.2250 (17) Å], forming a three-dimensional framework. |
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