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(2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo­[2,3-d]pyrimidin-7-yl)-5-methyl­tetra­hydro­furan-3,4-diol

The mol­ecular structure of the title compound, C(11)H(13)IN(4)O(3), shows a ribo­furanos­yl–pyrrolo O—C—N—C torsion angle of 59.1 (3)°, with the central C—N bond length being 1.446 (3) Å. The C—I bond length is 2.072 (2) Å. The amino group is coplanar with the attached aromatic ring [C—N—C—N torsio...

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Detalles Bibliográficos
Autores principales: Flörke, Ulrich, Drewes, Birte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884313/
https://www.ncbi.nlm.nih.gov/pubmed/24454089
http://dx.doi.org/10.1107/S1600536813027931
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author Flörke, Ulrich
Drewes, Birte
author_facet Flörke, Ulrich
Drewes, Birte
author_sort Flörke, Ulrich
collection PubMed
description The mol­ecular structure of the title compound, C(11)H(13)IN(4)O(3), shows a ribo­furanos­yl–pyrrolo O—C—N—C torsion angle of 59.1 (3)°, with the central C—N bond length being 1.446 (3) Å. The C—I bond length is 2.072 (2) Å. The amino group is coplanar with the attached aromatic ring [C—N—C—N torsion angle = −178.8 (2)°] and forms an intra­molecular N—H⋯I hydrogen bond. In the crystal, O—H⋯N and N—H⋯O hydrogen bonds link the mol­ecules into puckered layers parallel to (001). These layers are bound to each other by secondary I⋯O inter­actions [3.2250 (17) Å], forming a three-dimensional framework.
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spelling pubmed-38843132014-01-17 (2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo­[2,3-d]pyrimidin-7-yl)-5-methyl­tetra­hydro­furan-3,4-diol Flörke, Ulrich Drewes, Birte Acta Crystallogr Sect E Struct Rep Online Organic Papers The mol­ecular structure of the title compound, C(11)H(13)IN(4)O(3), shows a ribo­furanos­yl–pyrrolo O—C—N—C torsion angle of 59.1 (3)°, with the central C—N bond length being 1.446 (3) Å. The C—I bond length is 2.072 (2) Å. The amino group is coplanar with the attached aromatic ring [C—N—C—N torsion angle = −178.8 (2)°] and forms an intra­molecular N—H⋯I hydrogen bond. In the crystal, O—H⋯N and N—H⋯O hydrogen bonds link the mol­ecules into puckered layers parallel to (001). These layers are bound to each other by secondary I⋯O inter­actions [3.2250 (17) Å], forming a three-dimensional framework. International Union of Crystallography 2013-10-16 /pmc/articles/PMC3884313/ /pubmed/24454089 http://dx.doi.org/10.1107/S1600536813027931 Text en © Flörke and Drewes 2013 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Flörke, Ulrich
Drewes, Birte
(2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo­[2,3-d]pyrimidin-7-yl)-5-methyl­tetra­hydro­furan-3,4-diol
title (2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo­[2,3-d]pyrimidin-7-yl)-5-methyl­tetra­hydro­furan-3,4-diol
title_full (2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo­[2,3-d]pyrimidin-7-yl)-5-methyl­tetra­hydro­furan-3,4-diol
title_fullStr (2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo­[2,3-d]pyrimidin-7-yl)-5-methyl­tetra­hydro­furan-3,4-diol
title_full_unstemmed (2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo­[2,3-d]pyrimidin-7-yl)-5-methyl­tetra­hydro­furan-3,4-diol
title_short (2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo­[2,3-d]pyrimidin-7-yl)-5-methyl­tetra­hydro­furan-3,4-diol
title_sort (2r,3r,4s,5r)-2-(4-amino-5-iodo-7h-pyrrolo­[2,3-d]pyrimidin-7-yl)-5-methyl­tetra­hydro­furan-3,4-diol
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884313/
https://www.ncbi.nlm.nih.gov/pubmed/24454089
http://dx.doi.org/10.1107/S1600536813027931
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