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4-Methoxy-N-(pyridin-4-ylmethyl)-3-(trifluoromethyl)benzamide monohydrate
In the title compound, C(15)H(13)F(3)N(2)O(2)·H(2)O, the dihedral angle between the benzene and pyridine rings is 74.97 (1)°. The –CF(3) group attached to the benzene ring is syn to the C=O bond in the adjacent side chain. In the crystal, molecules are linked to one another through the water molec...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884365/ https://www.ncbi.nlm.nih.gov/pubmed/24454141 http://dx.doi.org/10.1107/S1600536813029103 |
Sumario: | In the title compound, C(15)H(13)F(3)N(2)O(2)·H(2)O, the dihedral angle between the benzene and pyridine rings is 74.97 (1)°. The –CF(3) group attached to the benzene ring is syn to the C=O bond in the adjacent side chain. In the crystal, molecules are linked to one another through the water molecules by strong N—H⋯O, O—H⋯O and O—H⋯N hydrogen bonds, forming a ladder-type network. The benzamide molecules are also linked to one another through C—H⋯F interactions, forming C(6) chains parallel to the b-axis direction. Aromatic π–π stacking interactions [centroid–centroid separations = 3.7150 (1) and 3.7857 (1) Å] between adjacent pairs of pyridine and benzene rings are also observed, resulting in a three-dimensional architecture are also observed. |
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