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4′-(1H-Imidazol-2-yl)-3′-[(1H-indol-3-yl)carbonyl]-1′-methyl-2-oxospiro[indoline-3,2′-pyrrolidine]-3′-carbonitrile 0.15-hydrate
In the title compound, C(25)H(20)N(6)O(2)·0.15H(2)O, the dihedral angles between the least-squares planes of the indole and pyrrolidine rings and between the oxindole and imidazole rings are 77.66 (7) and 45.31 (7)°, respectively. The pyrrolidine ring and the fused five-membered pyrrolidine ring of...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884395/ https://www.ncbi.nlm.nih.gov/pubmed/24427102 http://dx.doi.org/10.1107/S1600536813023246 |
Sumario: | In the title compound, C(25)H(20)N(6)O(2)·0.15H(2)O, the dihedral angles between the least-squares planes of the indole and pyrrolidine rings and between the oxindole and imidazole rings are 77.66 (7) and 45.31 (7)°, respectively. The pyrrolidine ring and the fused five-membered pyrrolidine ring of the oxindole moiety exhibit twisted conformations. The amide N atom is involved in both intra- and intermolecular hydrogen bonding, having a bifurcated character. The molecular structure is characterized by an intramolecular N—H⋯O hydrogen bond, which generates an S(7) ring motif while an intermolecular N—H⋯O hydrogen bond links the organic and solvent water molecules. In the crystal, N—H⋯N hydrogen bonds generate a zigzag chain running parallel to c-axis direction. The H atoms of the solvent water molecule were not located. |
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