Progenitor “Mycobacterium canettii” Clone Responsible for Lymph Node Tuberculosis Epidemic, Djibouti

“Mycobacterium canettii,” an opportunistic human pathogen living in an unknown environmental reservoir, is the progenitor species from which Mycobacterium tuberculosis emerged. Since its discovery in 1969, most of the ≈70 known M. canettii strains were isolated in the Republic of Djibouti, frequentl...

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Detalles Bibliográficos
Autores principales: Blouin, Yann, Cazajous, Géraldine, Dehan, Céline, Soler, Charles, Vong, Rithy, Hassan, Mohamed Osman, Hauck, Yolande, Boulais, Christian, Andriamanantena, Dina, Martinaud, Christophe, Martin, Émilie, Pourcel, Christine, Vergnaud, Gilles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884719/
https://www.ncbi.nlm.nih.gov/pubmed/24520560
http://dx.doi.org/10.3201/eid2001.130652
Descripción
Sumario:“Mycobacterium canettii,” an opportunistic human pathogen living in an unknown environmental reservoir, is the progenitor species from which Mycobacterium tuberculosis emerged. Since its discovery in 1969, most of the ≈70 known M. canettii strains were isolated in the Republic of Djibouti, frequently from expatriate children and adults. We show here, by whole-genome sequencing, that most strains collected from February 2010 through March 2013, and associated with 2 outbreaks of lymph node tuberculosis in children, belong to a unique epidemic clone within M. canettii. Evolution of this clone, which has been recovered regularly since 1983, may mimic the birth of M. tuberculosis. Thus, recognizing this organism and identifying its reservoir are clinically important.

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