The Structural Basis for Optimal Performance of Oligothiophene-Based Fluorescent Amyloid Ligands: Conformational Flexibility is Essential for Spectral Assignment of a Diversity of Protein Aggregates

Protein misfolding diseases are characterized by deposition of protein aggregates, and optical ligands for molecular characterization of these disease-associated structures are important for understanding their potential role in the pathogenesis of the disease. Luminescent conjugated oligothiophenes...

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Detalles Bibliográficos
Autores principales: Klingstedt, Therése, Shirani, Hamid, Åslund, K O Andreas, Cairns, Nigel J, Sigurdson, Christina J, Goedert, Michel, Nilsson*, K Peter R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2013
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884759/
https://www.ncbi.nlm.nih.gov/pubmed/23780508
http://dx.doi.org/10.1002/chem.201301463

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