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Enhanced Blood Pressure–Lowering Effect of Olmesartan in Hypertensive Patients With Chronic Kidney Disease–Associated Sympathetic Hyperactivity: HONEST Study

To investigate the blood pressure (BP)–lowering effect of olmesartan in relation to chronic kidney disease (CKD)–associated sympathetic nerve activity, a subanalysis was performed using data from the first 16 weeks of the Home BP Measurement With Olmesartan‐Naive Patients to Establish Standard Targe...

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Autores principales: Kario, Kazuomi, Saito, Ikuo, Kushiro, Toshio, Teramukai, Satoshi, Mori, Yoshihiro, Hiramatsu, Katsutoshi, Kobayashi, Fumiaki, Shimada, Kazuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884768/
https://www.ncbi.nlm.nih.gov/pubmed/23889717
http://dx.doi.org/10.1111/jch.12132
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author Kario, Kazuomi
Saito, Ikuo
Kushiro, Toshio
Teramukai, Satoshi
Mori, Yoshihiro
Hiramatsu, Katsutoshi
Kobayashi, Fumiaki
Shimada, Kazuyuki
author_facet Kario, Kazuomi
Saito, Ikuo
Kushiro, Toshio
Teramukai, Satoshi
Mori, Yoshihiro
Hiramatsu, Katsutoshi
Kobayashi, Fumiaki
Shimada, Kazuyuki
author_sort Kario, Kazuomi
collection PubMed
description To investigate the blood pressure (BP)–lowering effect of olmesartan in relation to chronic kidney disease (CKD)–associated sympathetic nerve activity, a subanalysis was performed using data from the first 16 weeks of the Home BP Measurement With Olmesartan‐Naive Patients to Establish Standard Target Blood Pressure (HONEST) study, a prospective observational study of hypertensive patients. Essential hypertensive patients who took no antihypertensive agent at baseline were classified based on baseline morning home systolic BP (MHSBP) in quartiles. In each class, patients were further classified based on baseline morning home pulse rate (MHPR). A subgroup analysis in patients with/without chronic kidney disease (CKD) was performed. A total of 5458 patients (mean age, 63.0 years; 51.6% women) were included. In the 4th quartile of baseline MHSBP (≥165 mm Hg), patients with MHPR ≥70 beats per minute had a greater BP reduction (by 3.2 mm Hg) than those with MHPR <70 beats per minute after 16 weeks of olmesartan‐based treatment (P=.0005). An even greater BP reduction (by 6.6 mm Hg) was observed in patients with CKD than in patients without CKD in this group (P=.0084). Olmesartan was more effective in hypertensive patients with high MHSBP and MHPR ≥70 beats per minute, especially in patients with CKD. Olmesartan may have enhanced BP‐lowering effects by improving renal ischemia in hypertensive CKD patients with potential increased sympathetic nerve activity.
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spelling pubmed-38847682014-01-13 Enhanced Blood Pressure–Lowering Effect of Olmesartan in Hypertensive Patients With Chronic Kidney Disease–Associated Sympathetic Hyperactivity: HONEST Study Kario, Kazuomi Saito, Ikuo Kushiro, Toshio Teramukai, Satoshi Mori, Yoshihiro Hiramatsu, Katsutoshi Kobayashi, Fumiaki Shimada, Kazuyuki J Clin Hypertens (Greenwich) Original Papers To investigate the blood pressure (BP)–lowering effect of olmesartan in relation to chronic kidney disease (CKD)–associated sympathetic nerve activity, a subanalysis was performed using data from the first 16 weeks of the Home BP Measurement With Olmesartan‐Naive Patients to Establish Standard Target Blood Pressure (HONEST) study, a prospective observational study of hypertensive patients. Essential hypertensive patients who took no antihypertensive agent at baseline were classified based on baseline morning home systolic BP (MHSBP) in quartiles. In each class, patients were further classified based on baseline morning home pulse rate (MHPR). A subgroup analysis in patients with/without chronic kidney disease (CKD) was performed. A total of 5458 patients (mean age, 63.0 years; 51.6% women) were included. In the 4th quartile of baseline MHSBP (≥165 mm Hg), patients with MHPR ≥70 beats per minute had a greater BP reduction (by 3.2 mm Hg) than those with MHPR <70 beats per minute after 16 weeks of olmesartan‐based treatment (P=.0005). An even greater BP reduction (by 6.6 mm Hg) was observed in patients with CKD than in patients without CKD in this group (P=.0084). Olmesartan was more effective in hypertensive patients with high MHSBP and MHPR ≥70 beats per minute, especially in patients with CKD. Olmesartan may have enhanced BP‐lowering effects by improving renal ischemia in hypertensive CKD patients with potential increased sympathetic nerve activity. John Wiley and Sons Inc. 2013-05-31 /pmc/articles/PMC3884768/ /pubmed/23889717 http://dx.doi.org/10.1111/jch.12132 Text en © 2013 The Authors. The Journal of Clinical Hypertension Published by Wiley Periodicals, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Papers
Kario, Kazuomi
Saito, Ikuo
Kushiro, Toshio
Teramukai, Satoshi
Mori, Yoshihiro
Hiramatsu, Katsutoshi
Kobayashi, Fumiaki
Shimada, Kazuyuki
Enhanced Blood Pressure–Lowering Effect of Olmesartan in Hypertensive Patients With Chronic Kidney Disease–Associated Sympathetic Hyperactivity: HONEST Study
title Enhanced Blood Pressure–Lowering Effect of Olmesartan in Hypertensive Patients With Chronic Kidney Disease–Associated Sympathetic Hyperactivity: HONEST Study
title_full Enhanced Blood Pressure–Lowering Effect of Olmesartan in Hypertensive Patients With Chronic Kidney Disease–Associated Sympathetic Hyperactivity: HONEST Study
title_fullStr Enhanced Blood Pressure–Lowering Effect of Olmesartan in Hypertensive Patients With Chronic Kidney Disease–Associated Sympathetic Hyperactivity: HONEST Study
title_full_unstemmed Enhanced Blood Pressure–Lowering Effect of Olmesartan in Hypertensive Patients With Chronic Kidney Disease–Associated Sympathetic Hyperactivity: HONEST Study
title_short Enhanced Blood Pressure–Lowering Effect of Olmesartan in Hypertensive Patients With Chronic Kidney Disease–Associated Sympathetic Hyperactivity: HONEST Study
title_sort enhanced blood pressure–lowering effect of olmesartan in hypertensive patients with chronic kidney disease–associated sympathetic hyperactivity: honest study
topic Original Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884768/
https://www.ncbi.nlm.nih.gov/pubmed/23889717
http://dx.doi.org/10.1111/jch.12132
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