A New Role of Vemurafenib as a Neoadjuvant Treatment of Axillary and Brain Melanoma Metastases

Vemurafenib is approved by the FDA for the management of unresectable or metastatic melanoma. However, its role as a neoadjuvant therapy has not been determined. We present the first documented case in which vemurafenib induced complete tumor necrosis of both lymph node and brain metastases within o...

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Detalles Bibliográficos
Autores principales: Melnik, Idit, Lotem, Michal, Yoffe, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884783/
https://www.ncbi.nlm.nih.gov/pubmed/24455362
http://dx.doi.org/10.1155/2013/794239
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author Melnik, Idit
Lotem, Michal
Yoffe, Boris
author_facet Melnik, Idit
Lotem, Michal
Yoffe, Boris
author_sort Melnik, Idit
collection PubMed
description Vemurafenib is approved by the FDA for the management of unresectable or metastatic melanoma. However, its role as a neoadjuvant therapy has not been determined. We present the first documented case in which vemurafenib induced complete tumor necrosis of both lymph node and brain metastases within one month or less, an outcome that indicated that the patient was a good candidate for excisional surgery.
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spelling pubmed-38847832014-01-21 A New Role of Vemurafenib as a Neoadjuvant Treatment of Axillary and Brain Melanoma Metastases Melnik, Idit Lotem, Michal Yoffe, Boris Case Rep Oncol Med Case Report Vemurafenib is approved by the FDA for the management of unresectable or metastatic melanoma. However, its role as a neoadjuvant therapy has not been determined. We present the first documented case in which vemurafenib induced complete tumor necrosis of both lymph node and brain metastases within one month or less, an outcome that indicated that the patient was a good candidate for excisional surgery. Hindawi Publishing Corporation 2013 2013-12-23 /pmc/articles/PMC3884783/ /pubmed/24455362 http://dx.doi.org/10.1155/2013/794239 Text en Copyright © 2013 Idit Melnik et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Melnik, Idit
Lotem, Michal
Yoffe, Boris
A New Role of Vemurafenib as a Neoadjuvant Treatment of Axillary and Brain Melanoma Metastases
title A New Role of Vemurafenib as a Neoadjuvant Treatment of Axillary and Brain Melanoma Metastases
title_full A New Role of Vemurafenib as a Neoadjuvant Treatment of Axillary and Brain Melanoma Metastases
title_fullStr A New Role of Vemurafenib as a Neoadjuvant Treatment of Axillary and Brain Melanoma Metastases
title_full_unstemmed A New Role of Vemurafenib as a Neoadjuvant Treatment of Axillary and Brain Melanoma Metastases
title_short A New Role of Vemurafenib as a Neoadjuvant Treatment of Axillary and Brain Melanoma Metastases
title_sort new role of vemurafenib as a neoadjuvant treatment of axillary and brain melanoma metastases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884783/
https://www.ncbi.nlm.nih.gov/pubmed/24455362
http://dx.doi.org/10.1155/2013/794239
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