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Target-based drug discovery for human African trypanosomiasis: selection of molecular target and chemical matter
Target-based approaches for human African trypanosomiasis (HAT) and related parasites can be a valuable route for drug discovery for these diseases. However, care needs to be taken in selection of both the actual drug target and the chemical matter that is developed. In this article, potential crite...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cambridge University Press
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884840/ https://www.ncbi.nlm.nih.gov/pubmed/23931634 http://dx.doi.org/10.1017/S0031182013001017 |
| Sumario: | Target-based approaches for human African trypanosomiasis (HAT) and related parasites can be a valuable route for drug discovery for these diseases. However, care needs to be taken in selection of both the actual drug target and the chemical matter that is developed. In this article, potential criteria to aid target selection are described. Then the physiochemical properties of typical oral drugs are discussed and compared to those of known anti-parasitics. |
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