Target-based drug discovery for human African trypanosomiasis: selection of molecular target and chemical matter

Target-based approaches for human African trypanosomiasis (HAT) and related parasites can be a valuable route for drug discovery for these diseases. However, care needs to be taken in selection of both the actual drug target and the chemical matter that is developed. In this article, potential crite...

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Detalles Bibliográficos
Autor principal: GILBERT, IAN H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884840/
https://www.ncbi.nlm.nih.gov/pubmed/23931634
http://dx.doi.org/10.1017/S0031182013001017
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author GILBERT, IAN H.
author_facet GILBERT, IAN H.
author_sort GILBERT, IAN H.
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description Target-based approaches for human African trypanosomiasis (HAT) and related parasites can be a valuable route for drug discovery for these diseases. However, care needs to be taken in selection of both the actual drug target and the chemical matter that is developed. In this article, potential criteria to aid target selection are described. Then the physiochemical properties of typical oral drugs are discussed and compared to those of known anti-parasitics.
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spelling pubmed-38848402014-01-08 Target-based drug discovery for human African trypanosomiasis: selection of molecular target and chemical matter GILBERT, IAN H. Parasitology Research Article Target-based approaches for human African trypanosomiasis (HAT) and related parasites can be a valuable route for drug discovery for these diseases. However, care needs to be taken in selection of both the actual drug target and the chemical matter that is developed. In this article, potential criteria to aid target selection are described. Then the physiochemical properties of typical oral drugs are discussed and compared to those of known anti-parasitics. Cambridge University Press 2014-01 2013-08-09 /pmc/articles/PMC3884840/ /pubmed/23931634 http://dx.doi.org/10.1017/S0031182013001017 Text en © Cambridge University Press 2013 The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution-NonCommercial-ShareAlike licence <http://creativecommons.org/licenses/by-nc-sa/3.0/>. The written permission of Cambridge University Press must be obtained for commercial re-use.
spellingShingle Research Article
GILBERT, IAN H.
Target-based drug discovery for human African trypanosomiasis: selection of molecular target and chemical matter
title Target-based drug discovery for human African trypanosomiasis: selection of molecular target and chemical matter
title_full Target-based drug discovery for human African trypanosomiasis: selection of molecular target and chemical matter
title_fullStr Target-based drug discovery for human African trypanosomiasis: selection of molecular target and chemical matter
title_full_unstemmed Target-based drug discovery for human African trypanosomiasis: selection of molecular target and chemical matter
title_short Target-based drug discovery for human African trypanosomiasis: selection of molecular target and chemical matter
title_sort target-based drug discovery for human african trypanosomiasis: selection of molecular target and chemical matter
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884840/
https://www.ncbi.nlm.nih.gov/pubmed/23931634
http://dx.doi.org/10.1017/S0031182013001017
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