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(S)-(+)-cis-4′-Benzyloxypraziquantel
The asymmetric unit of the title compound, C(26)H(30)N(2)O(3) {systematic name (S)-(+)-2-[cis-4-(benzyloxy)cyclohexanecarbonyl]-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one}, consists of two independent molecules in which the O= C(amide) group is syn to the N—C(C=O(lactam))...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885080/ https://www.ncbi.nlm.nih.gov/pubmed/24454256 http://dx.doi.org/10.1107/S1600536813031735 |
Sumario: | The asymmetric unit of the title compound, C(26)H(30)N(2)O(3) {systematic name (S)-(+)-2-[cis-4-(benzyloxy)cyclohexanecarbonyl]-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one}, consists of two independent molecules in which the O= C(amide) group is syn to the N—C(C=O(lactam)) moiety, making dihedral angles of 2.0 (8) and 3.7 (8)°. The conformation of the 1,4-disubstituted cyclohexane ring is cis in each independent molecule, with the carbonyl group occupying an equatorial position and the benzyloxy group an axial position. In one molecule, two C and one O atom of the benzyloxy group are disordered over two sets of sites, with a refined occupancy ratio of 0.772 (8):0.228 (8). In the crystal, molecules are linked by C—H⋯O interactions, forming ribbons parallel to the b-axis direction. |
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