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Molecular Features Related to HIV Integrase Inhibition Obtained from Structure- and Ligand-Based Approaches

Among several biological targets to treat AIDS, HIV integrase is a promising enzyme that can be employed to develop new anti-HIV agents. The aim of this work is to propose a mechanistic interpretation of HIV-1 integrase inhibition and to rationalize the molecular features related to the binding affi...

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Detalles Bibliográficos
Autores principales:	de Carvalho, Luciana L., Maltarollo, Vinícius G., de Lima, Emmanuela Ferreira, Weber, Karen C., Honorio, Kathia M., da Silva, Albérico B. F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885377/ https://www.ncbi.nlm.nih.gov/pubmed/24416129 http://dx.doi.org/10.1371/journal.pone.0081301

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