A Phase I Clinical Study of a Live Attenuated Bordetella pertussis Vaccine - BPZE1; A Single Centre, Double-Blind, Placebo-Controlled, Dose-Escalating Study of BPZE1 Given Intranasally to Healthy Adult Male Volunteers

BACKGROUND: Acellular pertussis vaccines do not control pertussis. A new approach to offer protection to infants is necessary. BPZE1, a genetically modified Bordetella pertussis strain, was developed as a live attenuated nasal pertussis vaccine by genetically eliminating or detoxifying 3 toxins. MET...

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Detalles Bibliográficos
Autores principales: Thorstensson, Rigmor, Trollfors, Birger, Al-Tawil, Nabil, Jahnmatz, Maja, Bergström, Jakob, Ljungman, Margaretha, Törner, Anna, Wehlin, Lena, Van Broekhoven, Annie, Bosman, Fons, Debrie, Anne-Sophie, Mielcarek, Nathalie, Locht, Camille
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885431/
https://www.ncbi.nlm.nih.gov/pubmed/24421886
http://dx.doi.org/10.1371/journal.pone.0083449

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