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Mutation Induced Conformational Changes in Genomic DNA from Cancerous K562 Cells Influence Drug-DNA Binding Modes

Normal human genomic DNA (N-DNA) and mutated DNA (M-DNA) from K562 leukemic cells show different thermodynamic properties and binding affinities on interaction with anticancer drugs; adriamycin (ADR) and daunomycin (DNM). Isothermal calorimetric thermograms representing titration of ADR/DNM with N-D...

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Detalles Bibliográficos
Autores principales:	Ghosh, Debjani, Dey, Subrata Kumar, Saha, Chabita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885628/ https://www.ncbi.nlm.nih.gov/pubmed/24416304 http://dx.doi.org/10.1371/journal.pone.0084880

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