Percutaneous transplantation of human umbilical cord-derived mesenchymal stem cells in a dog suspected to have fibrocartilaginous embolic myelopathy

The use of human umbilical cord blood-derived mesenchymal stem cells for cell transplantation therapy holds great promise for repairing spinal cord injury. Here we report the first clinical trial transplantation of human umbilical cord (hUCB)-derived mesenchymal stem cells (MSCs) into the spinal cor...

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Autores principales: Chung, Wook-Hun, Park, Seon-Ah, Lee, Jae-Hoon, Chung, Dai-Jung, Yang, Wo-Jong, Kang, Eun-Hee, Choi, Chi-Bong, Chang, Hwa-Seok, Kim, Dae-Hyun, Hwang, Soo-Han, Han, Hoon, Kim, Hwi-Yool
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Veterinary Science 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885746/
https://www.ncbi.nlm.nih.gov/pubmed/23820160
http://dx.doi.org/10.4142/jvs.2013.14.4.495
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author Chung, Wook-Hun
Park, Seon-Ah
Lee, Jae-Hoon
Chung, Dai-Jung
Yang, Wo-Jong
Kang, Eun-Hee
Choi, Chi-Bong
Chang, Hwa-Seok
Kim, Dae-Hyun
Hwang, Soo-Han
Han, Hoon
Kim, Hwi-Yool
author_facet Chung, Wook-Hun
Park, Seon-Ah
Lee, Jae-Hoon
Chung, Dai-Jung
Yang, Wo-Jong
Kang, Eun-Hee
Choi, Chi-Bong
Chang, Hwa-Seok
Kim, Dae-Hyun
Hwang, Soo-Han
Han, Hoon
Kim, Hwi-Yool
author_sort Chung, Wook-Hun
collection PubMed
description The use of human umbilical cord blood-derived mesenchymal stem cells for cell transplantation therapy holds great promise for repairing spinal cord injury. Here we report the first clinical trial transplantation of human umbilical cord (hUCB)-derived mesenchymal stem cells (MSCs) into the spinal cord of a dog suspected to have fibrocartilaginous embolic myelopathy (FCEM) and that experienced a loss of deep pain sensation. Locomotor functions improved following transplantation in a dog. Based on our findings, we suggest that transplantation of hUCB-derived MSCs will have beneficial therapeutic effects on FCEM patients lacking deep pain sensation.
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spelling pubmed-38857462014-01-13 Percutaneous transplantation of human umbilical cord-derived mesenchymal stem cells in a dog suspected to have fibrocartilaginous embolic myelopathy Chung, Wook-Hun Park, Seon-Ah Lee, Jae-Hoon Chung, Dai-Jung Yang, Wo-Jong Kang, Eun-Hee Choi, Chi-Bong Chang, Hwa-Seok Kim, Dae-Hyun Hwang, Soo-Han Han, Hoon Kim, Hwi-Yool J Vet Sci Case Report The use of human umbilical cord blood-derived mesenchymal stem cells for cell transplantation therapy holds great promise for repairing spinal cord injury. Here we report the first clinical trial transplantation of human umbilical cord (hUCB)-derived mesenchymal stem cells (MSCs) into the spinal cord of a dog suspected to have fibrocartilaginous embolic myelopathy (FCEM) and that experienced a loss of deep pain sensation. Locomotor functions improved following transplantation in a dog. Based on our findings, we suggest that transplantation of hUCB-derived MSCs will have beneficial therapeutic effects on FCEM patients lacking deep pain sensation. The Korean Society of Veterinary Science 2013-12 2013-12-19 /pmc/articles/PMC3885746/ /pubmed/23820160 http://dx.doi.org/10.4142/jvs.2013.14.4.495 Text en © 2013 The Korean Society of Veterinary Science. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Chung, Wook-Hun
Park, Seon-Ah
Lee, Jae-Hoon
Chung, Dai-Jung
Yang, Wo-Jong
Kang, Eun-Hee
Choi, Chi-Bong
Chang, Hwa-Seok
Kim, Dae-Hyun
Hwang, Soo-Han
Han, Hoon
Kim, Hwi-Yool
Percutaneous transplantation of human umbilical cord-derived mesenchymal stem cells in a dog suspected to have fibrocartilaginous embolic myelopathy
title Percutaneous transplantation of human umbilical cord-derived mesenchymal stem cells in a dog suspected to have fibrocartilaginous embolic myelopathy
title_full Percutaneous transplantation of human umbilical cord-derived mesenchymal stem cells in a dog suspected to have fibrocartilaginous embolic myelopathy
title_fullStr Percutaneous transplantation of human umbilical cord-derived mesenchymal stem cells in a dog suspected to have fibrocartilaginous embolic myelopathy
title_full_unstemmed Percutaneous transplantation of human umbilical cord-derived mesenchymal stem cells in a dog suspected to have fibrocartilaginous embolic myelopathy
title_short Percutaneous transplantation of human umbilical cord-derived mesenchymal stem cells in a dog suspected to have fibrocartilaginous embolic myelopathy
title_sort percutaneous transplantation of human umbilical cord-derived mesenchymal stem cells in a dog suspected to have fibrocartilaginous embolic myelopathy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885746/
https://www.ncbi.nlm.nih.gov/pubmed/23820160
http://dx.doi.org/10.4142/jvs.2013.14.4.495
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