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T cell immunodominance is dictated by the positively selecting self-peptide

Naive T cell precursor frequency determines the magnitude of immunodominance. While a broad T cell repertoire requires diverse positively selecting self-peptides, how a single positively selecting ligand influences naive T cell precursor frequency remains undefined. We generated a transgenic mouse e...

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Detalles Bibliográficos
Autores principales:	Lo, Wan-Lin, Solomon, Benjamin D, Donermeyer, David L, Hsieh, Chyi-Song, Allen, Paul M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2014
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885792/ https://www.ncbi.nlm.nih.gov/pubmed/24424413 http://dx.doi.org/10.7554/eLife.01457

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