Induction of a chloracne phenotype in an epidermal equivalent model by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is dependent on aryl hydrocarbon receptor activation and is not reproduced by aryl hydrocarbon receptor knock down

BACKGROUND: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent activator of the aryl hydrocarbon receptor (AhR) and causes chloracne in humans. The pathogenesis and role of AhR in chloracne remains incompletely understood. OBJECTIVE: To elucidate the mechanisms contributing to the development of...

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Detalles Bibliográficos
Autores principales: Forrester, Alison R., Elias, Martina S., Woodward, Emma L., Graham, Mark, Williams, Faith M., Reynolds, Nick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885976/
https://www.ncbi.nlm.nih.gov/pubmed/24161567
http://dx.doi.org/10.1016/j.jdermsci.2013.09.001

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