Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain

Highly pathogenic avian influenza H5N1 (HPAI H5N1) viruses can infect mammals, including humans, causing severe systemic disease with the inhibition of the immune system and a high mortality rate. In conditions of lymphoid tissue depletion, the liver plays an important role in host defence against v...

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Autores principales: Potapova, Oxana V., Sharkova, Tatyana V., Shkurupiy, Vyacheslav A., Shestopalov, Alexander M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886489/
https://www.ncbi.nlm.nih.gov/pubmed/24454472
http://dx.doi.org/10.1155/2013/342686
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author Potapova, Oxana V.
Sharkova, Tatyana V.
Shkurupiy, Vyacheslav A.
Shestopalov, Alexander M.
author_facet Potapova, Oxana V.
Sharkova, Tatyana V.
Shkurupiy, Vyacheslav A.
Shestopalov, Alexander M.
author_sort Potapova, Oxana V.
collection PubMed
description Highly pathogenic avian influenza H5N1 (HPAI H5N1) viruses can infect mammals, including humans, causing severe systemic disease with the inhibition of the immune system and a high mortality rate. In conditions of lymphoid tissue depletion, the liver plays an important role in host defence against viruses. The changes in mice liver infected with HPAI H5N1 virus A/goose/Krasnoozerskoye/627/05 have been studied. It has been shown that the virus persistence in the liver leads to the expression of proinflammatory cytokines (TNF-α, IL-6) and intracellular proteases (lysozyme, cathepsin D, and myeloperoxidase) by Kupffer cells. Defective antiviral response exacerbates destructive processes in the liver accelerating the development of liver failure.
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spelling pubmed-38864892014-01-21 Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain Potapova, Oxana V. Sharkova, Tatyana V. Shkurupiy, Vyacheslav A. Shestopalov, Alexander M. Clin Dev Immunol Research Article Highly pathogenic avian influenza H5N1 (HPAI H5N1) viruses can infect mammals, including humans, causing severe systemic disease with the inhibition of the immune system and a high mortality rate. In conditions of lymphoid tissue depletion, the liver plays an important role in host defence against viruses. The changes in mice liver infected with HPAI H5N1 virus A/goose/Krasnoozerskoye/627/05 have been studied. It has been shown that the virus persistence in the liver leads to the expression of proinflammatory cytokines (TNF-α, IL-6) and intracellular proteases (lysozyme, cathepsin D, and myeloperoxidase) by Kupffer cells. Defective antiviral response exacerbates destructive processes in the liver accelerating the development of liver failure. Hindawi Publishing Corporation 2013 2013-12-23 /pmc/articles/PMC3886489/ /pubmed/24454472 http://dx.doi.org/10.1155/2013/342686 Text en Copyright © 2013 Oxana V. Potapova et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Potapova, Oxana V.
Sharkova, Tatyana V.
Shkurupiy, Vyacheslav A.
Shestopalov, Alexander M.
Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain
title Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain
title_full Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain
title_fullStr Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain
title_full_unstemmed Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain
title_short Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain
title_sort immunomorphologic manifestations in mice liver infected with influenza a/h5n1, a/goose/krasnoozerskoye/627/05 strain
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886489/
https://www.ncbi.nlm.nih.gov/pubmed/24454472
http://dx.doi.org/10.1155/2013/342686
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