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Role of Omega-3 Polyunsaturated Fatty Acids in the Production of Prostaglandin E(2) and Nitric Oxide during Experimental Murine Paracoccidioidomycosis
There has recently been increased interest in the potential health effects of omega-3 polyunsaturated fatty acids on the immune system. Paracoccidioidomycosis is the most important endemic mycosis in Latin America. Macrophages have a fundamental role and act as first line of organism defense. The pu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886617/ https://www.ncbi.nlm.nih.gov/pubmed/24455741 http://dx.doi.org/10.1155/2013/947687 |
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author | Sargi, S. C. Dalalio, M. M. O. Moraes, A. G. Visentainer, J. E. L. Morais, D. R. Visentainer, J. V. |
author_facet | Sargi, S. C. Dalalio, M. M. O. Moraes, A. G. Visentainer, J. E. L. Morais, D. R. Visentainer, J. V. |
author_sort | Sargi, S. C. |
collection | PubMed |
description | There has recently been increased interest in the potential health effects of omega-3 polyunsaturated fatty acids on the immune system. Paracoccidioidomycosis is the most important endemic mycosis in Latin America. Macrophages have a fundamental role and act as first line of organism defense. The purpose of this study was to analyze the effect of n-3 fatty acids on the production of PGE(2) and NO by mice infected with Pb18 and fed a diet enriched with LNA for 8 weeks. To study the effect of omega-3 fatty acids on macrophage activity during experimental paracoccidioidomycosis, mice were infected with Pb18 and fed a diet supplemented with LNA. PGE(2) in the serum of animals was analyzed and NO in the supernatants of macrophages cultured and challenged in vitro with Pb18 was measured. Omega-3 fatty acids seemed to decrease the production of PGE(2) in vivo in the infected group fed an LNA-supplemented diet during the 4th and 8th weeks of the experiment. At the same time, we observed an increase in synthesis of NO by peritoneal macrophages in this group. Omega-3 fatty acids thus appear to have an immunomodulatory effect in paracoccidioidomycosis. |
format | Online Article Text |
id | pubmed-3886617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38866172014-01-21 Role of Omega-3 Polyunsaturated Fatty Acids in the Production of Prostaglandin E(2) and Nitric Oxide during Experimental Murine Paracoccidioidomycosis Sargi, S. C. Dalalio, M. M. O. Moraes, A. G. Visentainer, J. E. L. Morais, D. R. Visentainer, J. V. Biomed Res Int Research Article There has recently been increased interest in the potential health effects of omega-3 polyunsaturated fatty acids on the immune system. Paracoccidioidomycosis is the most important endemic mycosis in Latin America. Macrophages have a fundamental role and act as first line of organism defense. The purpose of this study was to analyze the effect of n-3 fatty acids on the production of PGE(2) and NO by mice infected with Pb18 and fed a diet enriched with LNA for 8 weeks. To study the effect of omega-3 fatty acids on macrophage activity during experimental paracoccidioidomycosis, mice were infected with Pb18 and fed a diet supplemented with LNA. PGE(2) in the serum of animals was analyzed and NO in the supernatants of macrophages cultured and challenged in vitro with Pb18 was measured. Omega-3 fatty acids seemed to decrease the production of PGE(2) in vivo in the infected group fed an LNA-supplemented diet during the 4th and 8th weeks of the experiment. At the same time, we observed an increase in synthesis of NO by peritoneal macrophages in this group. Omega-3 fatty acids thus appear to have an immunomodulatory effect in paracoccidioidomycosis. Hindawi Publishing Corporation 2013 2013-12-25 /pmc/articles/PMC3886617/ /pubmed/24455741 http://dx.doi.org/10.1155/2013/947687 Text en Copyright © 2013 S. C. Sargi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Sargi, S. C. Dalalio, M. M. O. Moraes, A. G. Visentainer, J. E. L. Morais, D. R. Visentainer, J. V. Role of Omega-3 Polyunsaturated Fatty Acids in the Production of Prostaglandin E(2) and Nitric Oxide during Experimental Murine Paracoccidioidomycosis |
title | Role of Omega-3 Polyunsaturated Fatty Acids in the Production of Prostaglandin E(2) and Nitric Oxide during Experimental Murine Paracoccidioidomycosis |
title_full | Role of Omega-3 Polyunsaturated Fatty Acids in the Production of Prostaglandin E(2) and Nitric Oxide during Experimental Murine Paracoccidioidomycosis |
title_fullStr | Role of Omega-3 Polyunsaturated Fatty Acids in the Production of Prostaglandin E(2) and Nitric Oxide during Experimental Murine Paracoccidioidomycosis |
title_full_unstemmed | Role of Omega-3 Polyunsaturated Fatty Acids in the Production of Prostaglandin E(2) and Nitric Oxide during Experimental Murine Paracoccidioidomycosis |
title_short | Role of Omega-3 Polyunsaturated Fatty Acids in the Production of Prostaglandin E(2) and Nitric Oxide during Experimental Murine Paracoccidioidomycosis |
title_sort | role of omega-3 polyunsaturated fatty acids in the production of prostaglandin e(2) and nitric oxide during experimental murine paracoccidioidomycosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886617/ https://www.ncbi.nlm.nih.gov/pubmed/24455741 http://dx.doi.org/10.1155/2013/947687 |
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