Structural basis of lentiviral subversion of a cellular protein degradation pathway

Lentiviruses contain accessory genes that have evolved to counteract the effects of host cellular defence proteins that inhibit productive infection. One such restriction factor, SAMHD1, inhibits HIV-1 infection of myeloid-lineage cells (1,2) as well as resting CD4(+) T cells (3,4) by reducing the c...

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Detalles Bibliográficos
Autores principales: Schwefel, David, Groom, Harriet C. T., Boucherit, Virginie C., Christodoulou, Evangelos, Walker, Philip A., Stoye, Jonathan P., Bishop, Kate N., Taylor, Ian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886899/
https://www.ncbi.nlm.nih.gov/pubmed/24336198
http://dx.doi.org/10.1038/nature12815

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886899/
https://www.ncbi.nlm.nih.gov/pubmed/24336198
http://dx.doi.org/10.1038/nature12815

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