Cofactor-Independent Phosphoglycerate Mutase from Nematodes Has Limited Druggability, as Revealed by Two High-Throughput Screens

Cofactor-independent phosphoglycerate mutase (iPGAM) is essential for the growth of C. elegans but is absent from humans, suggesting its potential as a drug target in parasitic nematodes such as Brugia malayi, a cause of lymphatic filariasis (LF). iPGAM's active site is small and hydrophilic, i...

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Detalles Bibliográficos
Autores principales: Crowther, Gregory J., Booker, Michael L., He, Min, Li, Ting, Raverdy, Sylvine, Novelli, Jacopo F., He, Panqing, Dale, Natalie R. G., Fife, Amy M., Barker, Robert H., Kramer, Martin L., Van Voorhis, Wesley C., Carlow, Clotilde K. S., Wang, Ming-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886921/
https://www.ncbi.nlm.nih.gov/pubmed/24416464
http://dx.doi.org/10.1371/journal.pntd.0002628

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