Graph Theory Enables Drug Repurposing – How a Mathematical Model Can Drive the Discovery of Hidden Mechanisms of Action

We introduce a methodology to efficiently exploit natural-language expressed biomedical knowledge for repurposing existing drugs towards diseases for which they were not initially intended. Leveraging on developments in Computational Linguistics and Graph Theory, a methodology is defined to build a...

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Detalles Bibliográficos
Autores principales: Gramatica, Ruggero, Di Matteo, T., Giorgetti, Stefano, Barbiani, Massimo, Bevec, Dorian, Aste, Tomaso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886994/
https://www.ncbi.nlm.nih.gov/pubmed/24416311
http://dx.doi.org/10.1371/journal.pone.0084912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886994/
https://www.ncbi.nlm.nih.gov/pubmed/24416311
http://dx.doi.org/10.1371/journal.pone.0084912

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