Bridging the Species Divide: Transgenic Mice Humanized for Type-I Interferon Response

We have generated transgenic mice that harbor humanized type I interferon receptors (IFNARs) enabling the study of type I human interferons (Hu-IFN-Is) in mice. These “HyBNAR” (Hybrid IFNAR) mice encode transgenic variants of IFNAR1 and IFNAR2 with the human extracellular domains being fused to tran...

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Detalles Bibliográficos
Autores principales: Harari, Daniel, Abramovich, Renne, Zozulya, Alla, Smith, Paul, Pouly, Sandrine, Köster, Mario, Hauser, Hansjörg, Schreiber, Gideon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887009/
https://www.ncbi.nlm.nih.gov/pubmed/24416207
http://dx.doi.org/10.1371/journal.pone.0084259

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