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Roles of the cellular prion protein in the regulation of cell-cell junctions and barrier function

The cellular prion protein was historically characterized owing to its misfolding in prion disease. Although its physiological role remains incompletely understood, PrP(C) has emerged as an evolutionary conserved, multifaceted protein involved in a wide-range of biological processes. PrP(C) is a GPI...

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Autores principales: Petit, Constance S.V., Besnier, Laura, Morel, Etienne, Rousset, Monique, Thenet, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887058/
https://www.ncbi.nlm.nih.gov/pubmed/24665391
http://dx.doi.org/10.4161/tisb.24377
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author Petit, Constance S.V.
Besnier, Laura
Morel, Etienne
Rousset, Monique
Thenet, Sophie
author_facet Petit, Constance S.V.
Besnier, Laura
Morel, Etienne
Rousset, Monique
Thenet, Sophie
author_sort Petit, Constance S.V.
collection PubMed
description The cellular prion protein was historically characterized owing to its misfolding in prion disease. Although its physiological role remains incompletely understood, PrP(C) has emerged as an evolutionary conserved, multifaceted protein involved in a wide-range of biological processes. PrP(C) is a GPI-anchored protein targeted to the plasma membrane, in raft microdomains, where its interaction with a repertoire of binding partners, which differ depending on cell models, mediates its functions. Among identified PrP(C) partners are cell adhesion molecules. This review will focus on the multiple implications of PrP(C) in cell adhesion processes, mainly the regulation of cell-cell junctions in epithelial and endothelial cells and the consequences on barrier properties. We will show how recent findings argue for a role of PrP(C) in the recruitment of signaling molecules, which in turn control the targeting or the stability of adhesion complexes at the plasma membrane.
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spelling pubmed-38870582014-02-19 Roles of the cellular prion protein in the regulation of cell-cell junctions and barrier function Petit, Constance S.V. Besnier, Laura Morel, Etienne Rousset, Monique Thenet, Sophie Tissue Barriers Review The cellular prion protein was historically characterized owing to its misfolding in prion disease. Although its physiological role remains incompletely understood, PrP(C) has emerged as an evolutionary conserved, multifaceted protein involved in a wide-range of biological processes. PrP(C) is a GPI-anchored protein targeted to the plasma membrane, in raft microdomains, where its interaction with a repertoire of binding partners, which differ depending on cell models, mediates its functions. Among identified PrP(C) partners are cell adhesion molecules. This review will focus on the multiple implications of PrP(C) in cell adhesion processes, mainly the regulation of cell-cell junctions in epithelial and endothelial cells and the consequences on barrier properties. We will show how recent findings argue for a role of PrP(C) in the recruitment of signaling molecules, which in turn control the targeting or the stability of adhesion complexes at the plasma membrane. Landes Bioscience 2013-04-01 2013-04-01 /pmc/articles/PMC3887058/ /pubmed/24665391 http://dx.doi.org/10.4161/tisb.24377 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Petit, Constance S.V.
Besnier, Laura
Morel, Etienne
Rousset, Monique
Thenet, Sophie
Roles of the cellular prion protein in the regulation of cell-cell junctions and barrier function
title Roles of the cellular prion protein in the regulation of cell-cell junctions and barrier function
title_full Roles of the cellular prion protein in the regulation of cell-cell junctions and barrier function
title_fullStr Roles of the cellular prion protein in the regulation of cell-cell junctions and barrier function
title_full_unstemmed Roles of the cellular prion protein in the regulation of cell-cell junctions and barrier function
title_short Roles of the cellular prion protein in the regulation of cell-cell junctions and barrier function
title_sort roles of the cellular prion protein in the regulation of cell-cell junctions and barrier function
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887058/
https://www.ncbi.nlm.nih.gov/pubmed/24665391
http://dx.doi.org/10.4161/tisb.24377
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