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Interleukin-21 Is a Critical Regulator of CD4 and CD8 T Cell Survival during Priming under Interleukin-2 Deprivation Conditions

Optimal T cell activation and expansion require binding of the common gamma-chain (γc) cytokine Interleukin-2 (IL-2) to its cognate receptor that in turn engages a γc/Janus tyrosine kinase (Jak)3 signaling pathway. Because of its restricted expression by antigen-activated T cells and its obligatory...

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Detalles Bibliográficos
Autores principales:	Khattar, Mithun, Miyahara, Yoshihiro, Schroder, Paul M., Xie, Aini, Chen, Wenhao, Stepkowski, Stanislaw M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887105/ https://www.ncbi.nlm.nih.gov/pubmed/24416451 http://dx.doi.org/10.1371/journal.pone.0085882

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